ArticlePsychological science2011
CHRM2, parental monitoring, and adolescent externalizing behavior: evidence for gene-environment interaction.
Article in Psychological science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Genetics of child aggression, a systematic review.Translational psychiatry · 2024Pooled it
- ORCHIDS: an observational randomized controlled trial on childhood differential susceptibility.BMC public health · 2012Trial
- Polygenic Risk for Substance Use Disorders as Predictors of Substance Use Initiation Among African American Youth.Journal of studies on alcohol and drugs · 2025Article
- The polarized mind in context: Interdisciplinary approaches to the psychology of political polarization.The American psychologist · 2022Article
- Utilising Genetically-Informed Research Designs to Better Understand Family Processes and Child Development: Implications for Adoption and Foster Care Focused Interventions.Adoption & fostering · 2019Article
- Adaptive developmental plasticity in rhesus macaques: the serotonin transporter gene interacts with maternal care to affect juvenile social behaviour.Proceedings. Biological sciences · 2018Article
- Naturalistic Experimental Designs as Tools for Understanding the Role of Genes and the Environment in Prevention Research.Prevention science : the official journal of the Society for Prevention Research · 2018Article
- Affiliation with substance-using peers: Examining gene-environment correlations among parent monitoring, polygenic risk, and children's impulsivity.Developmental psychobiology · 2017Article
- Roles of Response Inhibition and Gene-Environment Interplay in Pathways to Adolescents' Externalizing Problems.Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2017Article
- Socio-emotionally significant experience and children's processing of irrelevant auditory stimuli.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2017Article
- The Genetics of Addiction: Where Do We Go From Here?Journal of studies on alcohol and drugs · 2016Review
- The Genetic and Environmental Association Between Parental Monitoring and Risk of Cannabis, Stimulants, and Cocaine Initiation in a Sample of Male Twins: Does Parenting Matter?Twin research and human genetics : the official journal of the International Society for Twin Studies · 2016Article
- African-specific variability in the acetylcholine muscarinic receptor M4: association with cocaine and heroin addiction.Pharmacogenomics · 2016Article
- Person × Environment Interactions on Adolescent Delinquency: Sensation Seeking, Peer Deviance and Parental Monitoring.Personality and individual differences · 2015Article
- Gene-environment interactions and intermediate phenotypes: early trauma and depression.Frontiers in endocrinology · 2014Review
- Genetic differential sensitivity to social environments: implications for research.American journal of public health · 2013Article
- Preliminary evidence for a gene-environment interaction in predicting alcohol use disorders in adolescents.Alcoholism, clinical and experimental research · 2013Article
- From men to mice: CHRNA5/CHRNA3, smoking behavior and disease.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2012Review
- The genetics of addiction-a translational perspective.Translational psychiatry · 2012Review
- The influence of gene-environment interactions on the development of alcoholism and drug dependence.Current psychiatry reports · 2012Review
Corrections and comments
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Authors and funding
14 authors at 9 institutions in 2 countries.
Funding
Abstract
Psychologists, with their long-standing tradition of studying mechanistic processes, can make important contributions to further characterizing the risk associated with genes identified as influencing risk for psychiatric disorders. We report one such effort with respect to CHRM2, which codes for the cholinergic muscarinic 2 receptor and was of interest originally for its association with alcohol dependence. We tested for association between CHRM2 and prospectively measured externalizing behavior in a longitudinal, community-based sample of adolescents, as well as for moderation of this association by parental monitoring. We found evidence for an interaction in which the association between the genotype and externalizing behavior was stronger in environments with lower parental monitoring. There was also suggestion of a crossover effect, in which the genotype associated with the highest levels of externalizing behavior under low parental monitoring had the lowest levels of externalizing behavior at the extreme high end of parental monitoring. The difficulties involved in distinguishing mechanisms of gene-environment interaction are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.