Evidence map›Paper›PMID 21441220›Full record

ReviewJournal of dental research2011

Epithelial integrins with special reference to oral epithelia.

H Larjava, L Koivisto, L Häkkinen, J Heino

Abstract readReview
In one paragraph

Review in Journal of dental research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 120 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Transcriptomic Differences Between Immortalized Oral and Skin Keratinocytes.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Effect of TiOInternational journal of dentistry · 2024
    Review
  16. Review
  17. Mechanical Regulation of Oral Epithelial Barrier Function.Bioengineering (Basel, Switzerland) · 2023
    Article
  18. Influence of Surface Characteristics of TiOMaterials (Basel, Switzerland) · 2023
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

H LarjavaLaboratory of Periodontal Biology, Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, BC, Canada. larjava@interchange.ubc.ca
L Koivisto
L Häkkinen
J Heino
University of British Columbia · CAUniversity of Turku · FI

Funding

Psychosocial Influences on Rural Children's Oral HealthR01DE014899 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FOXMAN, BETSY, MARAZITA, MARY L. · 2002 to 2020
$39.9M
JH/CIDR Genotyping for Genome-Wide Association StudiesU01HG004438 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID · 2007 to 2011
$24.2M
Fluoride & Other Factors in Childhood and Adolescent Bone DevelopmentR01DE012101 · NIDCR · UNIVERSITY OF IOWA · PI LEVY, STEVEN M. · 1998 to 2013
$11.9M
THERMAL ASSEMBLY OF MINERAL/COLLAGEN BIOMATERIALSP60DE013076 · NIDCR · UNIVERSITY OF IOWA · PI MURRAY, JEFFREY C · 1999 to 2003
$8.4M
Genome Wide Association Coordinating CenterU01HG004446 · NHGRI · UNIVERSITY OF WASHINGTON · PI WEIR, BRUCE S. · 2007 to 2011
$6.6M
LONGITUDINAL STUDY OF FLUORIDE EXPOSURES &FLUORIDER01DE009551 · NIDCR · UNIVERSITY OF IOWA · PI LEVY, STEVEN M. · 1991 to 2008
$4.7M
Genome-wide association studies of prematurity and its complicationsU01HG004423 · NHGRI · UNIVERSITY OF IOWA · PI MURRAY, JEFFREY C · 2007 to 2010
$1.5M
Dental Caries: Whole Genome Association and Gene x Environment StudiesU01DE018903 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MARAZITA, MARY L. · 2007 to 2010
$1.2M
Statistical Modeling and Genetic Epidemiology of Dental Caries in GWAS AnalysisR03DE021425 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FEINGOLD, ELEANOR · 2011 to 2012
$455k
NHGRI NIH HHS HHSN268200782096CNHGRI NIH HHS U01 HG004423NHGRI NIH HHS U01-HG004423NHGRI NIH HHS U01 HG004438NHGRI NIH HHS U01-HG004438NHGRI NIH HHS U01 HG004446NHGRI NIH HHS U01-HG004446NIDCR NIH HHS P60 DE013076NIDCR NIH HHS P60-DE-13076NIDCR NIH HHS R01 DE009551NIDCR NIH HHS R01 DE012101NIDCR NIH HHS R01 DE014899NIDCR NIH HHS R01-DE014899NIDCR NIH HHS R01-DE0 9551NIDCR NIH HHS R01-DE12101NIDCR NIH HHS R03 DE021425NIDCR NIH HHS R03-DE021425NIDCR NIH HHS U01 DE018903NIDCR NIH HHS U01-DE018903
6 · The paper itself

Abstract

Adhesion of epithelium to the extracellular matrix is crucial for the maintenance of systemic and oral health. In the oral cavity, teeth or artificial dental implants penetrate the soft tissue of the gingiva. In this interface, gingival soft tissue needs to be well attached via the epithelial seal to the tooth or implant surface to maintain health. After injury or wounding, epithelial tissue rapidly migrates to form the initial epithelial cover to restore the barrier against infection. These events are crucially dependent on deposition of extracellular matrix and proper activation and function of integrin receptors in the epithelial cells. Recent experimental evidence suggests that epithelial integrins also participate in the regulation of periodontal inflammation. In this review, we will discuss the structure and function of epithelial integrins and their extracellular ligands and elaborate on their potential role in disease and repair processes in the oral cavity.

Indexed as

AnimalsCell AdhesionEpithelial AttachmentExtracellular Matrix ProteinsHumansIntegrin alpha6beta4IntegrinsKeratinocytesMouth MucosaProtein BindingProtein Structure, TertiaryTransforming Growth Factor beta1Wound HealingExtracellular Matrix ProteinsIntegrin alpha6beta4IntegrinsTransforming Growth Factor beta1

Identifiers

PMID21441220
PMCPMC3215754
OpenAlexW1972962509

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.