Evidence map›Paper›PMID 21441148›Full record

Trial reportStroke2011

Noninvasive brain stimulation may improve stroke-related dysphagia: a pilot study.

Sandeep Kumar, Cynthia W Wagner, Colleen Frayne, Lin Zhu, Magdy Selim, Wuwei Feng, Gottfried Schlaug

4 registry-linked trialsOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Stroke, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 74 papers, 18 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 18 pooled it
7.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01132066 phase1 / phase2completednot on this map

Pilot Study of Transcranial Direct Current Stimulation for Facilitating Swallowing Improvement After an Acute Unilateral Hemispheric Infarction

TypeinterventionalSponsorBeth Israel Deaconess Medical CenterRan2007 to 2013Enrolled19ConditionsDysphagiaArmstDCS, Sham
NCT05720871 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Treatment of Chronic Post-stroke Oropharyngeal Dysphagia With Paired Stimulation Through Peripheral TRVP1 Agonists and Non-invasive Brain Stimulation

TypeinterventionalSponsorHospital de MataróRan2022 to 2025Enrolled200ConditionsOropharyngeal Dysphagia, Stroke, Stroke, Complication, Swallowing DisorderArmsrTMS + capsaicin 150μM (natural TRPV1 agonist), tDCS + capsaicin 150μM (natural TRPV1 agonist)
NCT05735626 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Treatment of Acute Post-stroke Oropharyngeal Dysphagia With Paired Stimulation Through Peripheral TRVP1 Agonists and Non-invasive Brain Stimulation

TypeinterventionalSponsorHospital de MataróRan2021 to 2024Enrolled60ConditionsStroke, Stroke, Acute, Oropharyngeal Dysphagia, Swallowing DisorderArmsPiperine 150μM + tDCS 2mA, Piperine 1mM + tDCS 2mA, Capsaicin 10μM + tDCS 2mA
NCT07152899 nacompletednot on this mapstarted 2021, after this paper: background citation

New Approaches for the Treatment of Post-stroke Dysphagia and Dysphagia in Parkinson's Disease

TypeinterventionalSponsorIRCCS National Neurological Institute "C. Mondino" FoundationRan2021 to 2025Enrolled110ConditionsStroke, Complication, Parkinson's DiseaseArmsUnilateral anodal tDCS, Bihemispheric anodal tDCS, Sham tDCS, NMES + swallowing therapy, Sham NMES + swallowing therapy
3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 18 syntheses or guidelines pooled it, 173 citations in OpenAlex.

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  4. Efficacy of transcranial direct current stimulation in patients with dysphagia after stroke: a systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
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  15. Swallowing therapy for dysphagia in acute and subacute stroke.The Cochrane database of systematic reviews · 2018
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  17. Effects of non-invasive brain stimulation on post-stroke dysphagia: A systematic review and meta-analysis of randomized controlled trials.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2016
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14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Sandeep KumarDepartment of Neurology, Stroke Division, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Palmer 127 Boston, MA 02215, USA. skumar@bidmc.harvard.edu
Cynthia W Wagner
Colleen Frayne
Lin Zhu
Magdy Selim
Wuwei Feng
Gottfried Schlaug
Beth Israel Deaconess Medical Center · US

Funding

Insulin Resistance Intervention after Stroke TrialU01NS044876 · NINDS · YALE UNIVERSITY · PI KERNAN, WALTER N · 2004 to 2013
$73.6M
CEREBRAL MECHANISMS UNDERLYING DYSPNEAR01HL046690 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI BANZETT, ROBERT B · 1991 to 2007
$2.8M
Behavioral and Neural Correlates of Melodic Intonation TherapyR01DC008796 · NIDCD · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SCHLAUG, GOTTFRIED · 2008 to 2012
$2.0M
Neural Control of Vocal Production in Tone-DeafnessR01DC009823 · NIDCD · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SCHLAUG, GOTTFRIED · 2009 to 2013
$1.7M
Facilitators of Motor Recovery Following StrokeR01NS045049 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SCHLAUG, GOTTFRIED · 2004 to 2007
$1.3M
Safety and Tolerability of Deferoxamine in Acute Cerebral HemorrhageR01NS057127 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SELIM, MAGDY H · 2008 to 2010
$1.0M
NHLBI NIH HHS 5R01-HL46690-14NHLBI NIH HHS R01 HL046690NIDCD NIH HHS 1R01 DC008796NIDCD NIH HHS 3R01DC008796-02S1NIDCD NIH HHS R01 DC008796NIDCD NIH HHS R01 DC009823NIDCD NIH HHS R01 DC009823-01NINDS NIH HHS 1R01-NS 045754-01A2NINDS NIH HHS 1R01-NS057127NINDS NIH HHS 1R01-NS057127-01A1NINDS NIH HHS 5UO1-NS044876-03NINDS NIH HHS R01 NS045049NINDS NIH HHS R01 NS057127NINDS NIH HHS U01 NS044876
6 · The paper itself

Abstract

background and purposeTreatment options for stroke-related dysphagia are currently limited. In this study, we investigated whether noninvasive brain stimulation in combination with swallowing maneuvers facilitates swallowing recovery in dysphagic stroke patients during early stroke convalescence.

methodsFourteen patients with subacute unilateral hemispheric infarction were randomized to anodal transcranial direct current stimulation (tDCS) versus sham stimulation to the sensorimotor cortical representation of swallowing in the unaffected hemisphere over the course of 5 consecutive days with concurrent standardized swallowing maneuvers. Severity of dysphagia was measured using a validated swallowing scale, Dysphagia Outcome and Severity scale, before the first and after the last session of tDCS or sham. The effect of tDCS was analyzed in a multivariate linear regression model using changes in Dysphagia Outcome and Severity Scale as the outcome variable after adjusting for the effects of other potential confounding variables such as the National Institutes of Health Stroke Scale and Dysphagia Outcome and Severity scale scores at baseline, acute ischemic lesion volumes, patient age, and time from stroke onset to stimulation.

resultsPatients who received anodal tDCS gained 2.60 points of improvement in Dysphagia Outcome and Severity scale scores compared to patients in the sham stimulation group who showed an improvement of 1.25 points (P=0.019) after controlling for the effects of other aforementioned variables. Six out 7 (86%) patients in tDCS stimulation group gained at least 2 points of improvement compared with 3 out 7 (43%) patients in the sham group (P=0.107).

conclusionsBecause brain stem swallowing centers have bilateral cortical innervations, measures that enhance cortical input and sensorimotor control of brain stem swallowing may be beneficial for dysphagia recovery.

Indexed as

AgedAged, 80 and overDeglutition DisordersElectric Stimulation TherapyFemaleHumansMaleMiddle AgedPilot ProjectsProspective StudiesRecovery of FunctionSingle-Blind MethodStrokeTreatment Outcome

Identifiers

PMID21441148
PMCPMC3116809
OpenAlexW2065145128

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.