ArticleClinical journal of the American Society of Nephrology : CJASN2011
Determinants of osteopenia in male renal-stone-disease patients with idiopathic hypercalciuria.
Article in Clinical journal of the American Society of Nephrology : CJASN, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Prevalence of osteoporosis in patients with nephrolithiasis andFrontiers in endocrinology · 2023Pooled it
- Metabolic diagnosis and medical prevention of calcium nephrolithiasis and its systemic manifestations: a consensus statement.Journal of nephrology · 2016Guideline
- Nephrolithiasis, bone mineral density, osteoporosis, and fractures: a systematic review and comparative meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016Pooled it
- Hydrochlorothiazide and Bone Mineral Density in Patients with Kidney Stones: Post Hoc Analysis of the NOSTONE Trial.Clinical journal of the American Society of Nephrology : CJASN · 2025Article
- Between a Rock and a Short Place-The Impact of Nephrolithiasis on Skeletal Growth and Development Across the Lifespan.Current osteoporosis reports · 2024Review
- Risk factors for the comorbidity of osteoporosis/osteopenia and kidney stones: a cross-sectional study.Archives of osteoporosis · 2023Article
- Correlation Between Renal Calculus Disease and Iliac Bone Thickness on a Single Non-contrast CT Scan.Cureus · 2023Article
- Vitamin D and Calcium Supplementation and Urolithiasis: A Controversial and Multifaceted Relationship.Nutrients · 2023Review
- Pediatric Nephrolithiasis.Healthcare (Basel, Switzerland) · 2023Review
- The Reciprocal Relationship between Osteoporosis and Renal Stones.Journal of clinical medicine · 2022Article
- How useful is an oral calcium load test for diagnosing recurrent calcium stone formers?Urolithiasis · 2022Article
- UPDATE - Canadian Urological Association guideline: Evaluation and medical management of kidney stones.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2022Article
- Predictors of Bone Mineral Density in Kidney Stone Formers.Kidney international reports · 2022Article
- Metabolic effects of cholecalciferol supplementation in patients with calcium nephrolithiasis and vitamin D deficiency.World journal of urology · 2021Article
- Prevalence of idiopathic hypercalciuria in children with urinary system related symptoms attending a pediatric hospital in Bandar Abbas in 2014.Electronic physician · 2017Article
- The variation in urinary calcium levels in adult patients with fracture and surgical intervention.Journal of orthopaedic surgery and research · 2017Article
- Relationship between Urinary Calcium and Bone Mineral Density in Patients with Calcium Nephrolithiasis.The Journal of urology · 2017Article
- The importance of calciuria as lithogenic factors in patients with osteopenia/osteoporosis.International urology and nephrology · 2015Article
- Demographics and characterization of 10,282 Randall plaque-related kidney stones: a new epidemic?Medicine · 2015Article
- Vascular calcification and bone mineral density in recurrent kidney stone formers.Clinical journal of the American Society of Nephrology : CJASN · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesBone demineralization is frequent in renal-stone formers with hypercalciuria. Although this pathologic link has been recognized for decades, the underlying mechanisms and risk factors associated with osteopenia/osteoporosis in this population remain partially understood. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: This study retrospectively analyzed determinants of low bone mineral density (BMD) in 65 idiopathic hypercalciuric male renal-stone formers. Clinical and biologic evaluation included BMD measurement, bone-remodeling markers, analysis of calcium metabolism with oral calcium load test, and dietary inquiry.
resultsPatients with osteopenia (n=23, 35% of the population) presented significantly higher fasting calciuria as compared with normal bone density patients (n=42) (calcium/creatinine ratio was 0.32 versus 0.24 mmol/mmol; P=0.006). Analysis of the whole population revealed a negative association between fasting hypercalciuria and BMD (P = 0.003), independent of confounding variables including body-mass index and tobacco consumption. The fasting calcium/creatinine ratio above 0.25 mmol/mmol was associated with a 3.8-fold increase in the risk of low BMD.
conclusionIn our study, fasting hypercalciuria after a 2-day calcium-restricted diet appears as the only biologic factor associated with low BMD, suggesting a bone-calcium efflux. Our results support the view of a parathyroid-independent pathologic process that remains to be identified. Hypercalciuric patients with low BMD do not excrete more calcium in 24-hour urine samples than patients without low BMD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.