ArticleNeurobiology of disease2011
Ferritin overexpression in Drosophila glia leads to iron deposition in the optic lobes and late-onset behavioral defects.
Article in Neurobiology of disease, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Glial ferritin maintains neural stem cells via transporting iron required for self-renewal ineLife · 2024Article
- Differential gene expression of Asian citrus psyllids infected with 'Frontiers in plant science · 2023Article
- Clinical and Molecular Aspects of Iron Metabolism in Failing Myocytes.Life (Basel, Switzerland) · 2022Review
- Conserved Tao Kinase Activity Regulates Dendritic Arborization, Cytoskeletal Dynamics, and Sensory Function inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- The Magnetic Receptor ofFrontiers in microbiology · 2020Article
- Impact of Autophagy and Aging on Iron Load and Ferritin inFrontiers in cell and developmental biology · 2019Article
- The TinyInternational journal of molecular sciences · 2018Review
- Iron Sulfur and Molybdenum Cofactor Enzymes Regulate theFrontiers in physiology · 2018Article
- Ferritin Assembly in Enterocytes of Drosophila melanogaster.International journal of molecular sciences · 2016Article
- Glia in Drosophila behavior.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2015Review
- Article
- Behavioral decline and premature lethality upon pan-neuronal ferritin overexpression in Drosophila infected with a virulent form of Wolbachia.Frontiers in pharmacology · 2014Article
- Iron absorption in Drosophila melanogaster.Nutrients · 2013Review
- Insertion mutants in Drosophila melanogaster Hsc20 halt larval growth and lead to reduced iron-sulfur cluster enzyme activities and impaired iron homeostasis.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2013Article
- Gene duplication, tissue-specific gene expression and sexual conflict in stalk-eyed flies (Diopsidae).Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2012Review
- Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 4 countries.
Funding
Abstract
Cellular and organismal iron storage depends on the function of the ferritin protein complex in insects and mammals alike. In the central nervous system of insects, the distribution and relevance of ferritin remain unclear, though ferritin has been implicated in Drosophila models of Alzheimers' and Parkinsons' disease and in Aluminum-induced neurodegeneration. Here we show that transgene-derived expression of ferritin subunits in glial cells of Drosophila melanogaster causes a late-onset behavioral decline, characterized by loss of circadian rhythms in constant darkness and impairment of elicited locomotor responses. Anatomical analysis of the affected brains revealed crystalline inclusions of iron-loaded ferritin in a subpopulation of glial cells but not significant neurodegeneration. Although transgene-induced glial ferritin expression was well tolerated throughout development and in young flies, it turned disadvantageous at older age. The flies we characterize in this report contribute to the study of ferritin in the Drosophila brain and can be used to assess the contribution of glial iron metabolism in neurodegenerative models of disease.
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Registered trials
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