ArticleMicrobial pathogenesis
Features of sepsis caused by pulmonary infection with Francisella tularensis Type A strain.
Article in Microbial pathogenesis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 63 citations in OpenAlex.
- De Novo Design of High-Affinity Miniprotein Binders Targeting Francisella Tularensis Virulence Factor.Angewandte Chemie (International ed. in English) · 2025Article
- Pathogenicity and virulence ofVirulence · 2023Review
- Chronically hypertensive transgenic mice expressing human AT1R haplotype-I exhibit increased susceptibility toFrontiers in microbiology · 2023Article
- Novel Transcriptional and Translational Biomarkers of Tularemia Vaccine Efficacy in a Mouse Inhalation Model: Proof of Concept.Microorganisms · 2021Article
- The 'cytokine storm': molecular mechanisms and therapeutic prospects.Trends in immunology · 2021Review
- Deletion Mutants ofPathogens (Basel, Switzerland) · 2021Article
- Characterization of Schu S4Virulence · 2020Article
- QTY Code-designed Water-soluble Fc-fusion Cytokine Receptors Bind to their Respective Ligands.QRB discovery · 2020Article
- Design, synthesis, and screening of sulfonylurea-derived NLRP3 inflammasome inhibitors.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2020Article
- Production of Neutrophil Extracellular Traps Contributes to the Pathogenesis ofFrontiers in immunology · 2020Article
- Contributions of TolC Orthologs toInfection and immunity · 2019Article
- Detrimental Influence of Alveolar Macrophages on Protective Humoral Immunity during Francisella tularensis SchuS4 Pulmonary Infection.Infection and immunity · 2018Article
- Deletion of the Major Facilitator Superfamily TransporterInfection and immunity · 2018Article
- Obesity Exacerbates the Cytokine Storm Elicited byBioMed research international · 2018Article
- The Early Dendritic Cell Signaling Induced by VirulentMolecular & cellular proteomics : MCP · 2018Article
- Hematopoietic MyD88 and IL-18 are essential for IFN-γ-dependent restriction of type AJournal of leukocyte biology · 2017Article
- Protective Role for Macrophages in Respiratory Francisella tularensis Infection.Infection and immunity · 2017Article
- Lipoxin A4, a 5-lipoxygenase pathway metabolite, modulates immune response during acute respiratory tularemia.Journal of leukocyte biology · 2017Article
- The Natural History of Pneumonic Tularemia in Female Fischer 344 Rats after Inhalational Exposure to Aerosolized Francisella tularensis Subspecies tularensis Strain SCHU S4.The American journal of pathology · 2017Article
- Necroptotic debris including damaged mitochondria elicits sepsis-like syndrome during late-phase tularemia.Cell death discovery · 2017Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The virulence mechanisms of Francisella tularensis, the causative agent of severe pneumonia in humans and a CDC category A bioterrorism agent, are not fully defined. As sepsis is the leading cause of mortality associated with respiratory infections, we determined whether, in the absence of any known bacterial toxins, a deregulated host response resulting in sepsis syndrome is associated with lethality of respiratory infection with the virulent human Type A strain SchuS4 of F. tularensis. The C57BL/6 mice infected intranasally with a lethal dose of SchuS4 exhibited high bacterial burden in systemic organs and blood indicative of bacteremia. In correlation, infected mice displayed severe tissue pathology and associated cell death in lungs, liver and spleen. Consistent with our studies with murine model strain Francisella novicida, infection with SchuS4 caused an initial delay in upregulation of inflammatory mediators followed by development of severe sepsis characterized by exaggerated cytokine release, upregulation of cardiovascular injury markers and sepsis mediator alarmins S100A9 and HMGB1. This study shows that pulmonary tularemia caused by the Type A strain of F. tularensis results in a deregulated host response leading to severe sepsis and likely represents the major cause of mortality associated with this virulent pathogen.
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