ArticleMolecular immunology2011
2B4 utilizes ITAM-containing receptor complexes to initiate intracellular signaling and cytolysis.
Article in Molecular immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- 2B4/CD244 Signaling in Immune Regulation and Its Role in Infection, Cancer, and Immune Tolerance.ImmunoTargets and therapy · 2025Review
- NK cell recognition of hematopoietic cells by SLAM-SAP families.Cellular & molecular immunology · 2019Review
- Downregulation of CD3ζ in NK Cells from Systemic Lupus Erythematosus Patients Confers a Proinflammatory Phenotype.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Article
- NKp46 Clusters at the Immune Synapse and Regulates NK Cell Polarization.Frontiers in immunology · 2015Article
- Homotypic NK cell-to-cell communication controls cytokine responsiveness of innate immune NK cells.Scientific reports · 2014Article
- Article
- Identification of human NK cells that are deficient for signaling adaptor FcRγ and specialized for antibody-dependent immune functions.International immunology · 2012Article
- Characterization of Ly108 in the thymus: evidence for distinct properties of a novel form of Ly108.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- The adaptor protein SAP directly associates with CD3ζ chain and regulates T cell receptor signaling.PloS one · 2012Article
- SAP-mediated inhibition of diacylglycerol kinase α regulates TCR-induced diacylglycerol signaling.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
2B4 is a member of the SLAM receptor family capable of activating NK cell cytotoxicity in the context of EBV infection. SAP (SLAM Associated Protein) deficiency causes defective signaling downstream of SLAM family receptors and high susceptibility to EBV. 2B4 costimulates natural cytotoxicity receptor (NCR) and TCR initiated signals to induce cellular cytotoxicity and cytokine release. The 2B4-SAP signal transduction pathway is not predicted to overlap with the TCR-ITAM pathway, although SAP is required for some TCR-induced signals. We therefore examined the functional relationship between SLAM family receptor 2B4 and ITAM-containing adaptor complexes. Removal of FcɛRIγ or CD3ζ-containing complexes, using genetically manipulated cell lines or siRNA specific suppression, significantly reduces 2B4-initiated functions in NK and T cells, respectively. Consistent with this relationship, Syk and ZAP-70 are capable of transducing 2B4 signals for calcium mobilization and cytolysis. Furthermore, ITAM-containing molecules constitutively associate with SAP. These results suggest a potential physical association between 2B4 and the ITAM receptor complexes that is required for 2B4-initiated signaling and cell-mediated killing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.