ReviewNeuroscience letters2011
Human clinical trails in antiepileptogenesis.
Review in Neuroscience letters, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The primary prevention of epilepsy: A report of the Prevention Task Force of the International League Against Epilepsy.Epilepsia · 2018Pooled it
- Selected Molecular Targets for Counteracting Epileptogenesis: What Do We Know About Its Effective Inhibition?Current issues in molecular biology · 2026Review
- Oxidative Stress and Neurodegeneration in Animal Models of Seizures and Epilepsy.Antioxidants (Basel, Switzerland) · 2023Review
- Antiepileptogenesis and disease modification: Clinical and regulatory issues.Epilepsia open · 2021Article
- Anti-Epileptogenic Effects of Antiepileptic Drugs.International journal of molecular sciences · 2020Review
- How to Find Candidate Drug-targets for Antiepileptogenic Therapy?Current neuropharmacology · 2020Review
- Novel therapeutic approaches for disease-modification of epileptogenesis for curing epilepsy.Biochimica et biophysica acta. Molecular basis of disease · 2017Review
- Prevention of Epilepsy: Issues and Innovations.Current neurology and neuroscience reports · 2016Review
- Review
- Evaluating an etiologically relevant platform for therapy development for temporal lobe epilepsy: effects of carbamazepine and valproic acid on acute seizures and chronic behavioral comorbidities in the Theiler's murine encephalomyelitis virus mouse model.The Journal of pharmacology and experimental therapeutics · 2015Article
- Hippocampal neuro-networks and dendritic spine perturbations in epileptogenesis are attenuated by neuroprotectin d1.PloS one · 2015Article
- Anti-epileptogenic clinical trial designs in epilepsy: issues and options.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2014Review
- Neuroimaging the epileptogenic process.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2014Review
- Searching for the ideal antiepileptogenic agent in experimental models: single treatment versus combinatorial treatment strategies.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2014Review
- Post-traumatic epilepsy: current and emerging treatment options.Neuropsychiatric disease and treatment · 2014Review
- New avenues for anti-epileptic drug discovery and development.Nature reviews. Drug discovery · 2013Review
- Issues related to development of antiepileptogenic therapies.Epilepsia · 2013Review
- Novel frontiers in epilepsy treatments: preventing epileptogenesis by targeting inflammation.Expert review of neurotherapeutics · 2013Review
- Role of hormones and neurosteroids in epileptogenesis.Frontiers in cellular neuroscience · 2013Article
- Prospects for imaging-related biomarkers of human epileptogenesis: a critical review.Biomarkers in medicine · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Blocking the development of epilepsy (epileptogenesis) is a fundamental research area with the potential to provide large benefits to patients by avoiding the medical and social consequences that occur with epilepsy and lifelong therapy. Human clinical trials attempting to prevent epilepsy (antiepileptogenesis) have been few and universally unsuccessful to date. In this article, we review data about possible pathophysiological mechanisms underlying epileptogenesis, discuss potential interventions, and summarize prior antiepileptogenesis trials. Elements of ideal trials designs for successful antiepileptogenic intervention are suggested.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.