ReviewAntiviral research2011
Cytomegalovirus reactivation in critically ill immunocompetent hosts: a decade of progress and remaining challenges.
Review in Antiviral research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 68 citations in OpenAlex.
- ICU-acquired pneumonia beyond pathogen detection.Nature communications · 2026Review
- Article
- Associated Factors on Cytomegalovirus Reactivation in Patients with COVID-19 in the Intensive Care Unit.Mediterranean journal of hematology and infectious diseases · 2026Article
- Reactivation ofCase reports in infectious diseases · 2026Article
- Translating insights into therapies for Long Covid.Science translational medicine · 2024Review
- Review
- Role of Preemptive Cytomegalovirus Hyperimmunoglobulin in Cytomegalovirus Viremia Following Stem Cell Transplant: An Integrative Review.Journal of the advanced practitioner in oncology · 2023Review
- Regulatory effect of Pseudomonas aeruginosa mannose-sensitive hemagglutinin on inflammation and immune function in percutaneous nephrolithotomy patients with upper urinary tract calculi complicated with infection.Frontiers in immunology · 2023Article
- Decadal Journey of CNT-Based Analytical Biosensing Platforms in the Detection of Human Viruses.Nanomaterials (Basel, Switzerland) · 2022Review
- Article
- Identifying Potential Effective Diagnostic and Prognostic Biomarkers in Sepsis by Bioinformatics Analysis and Validation.International journal of general medicine · 2022Article
- CMV seropositivity is a potential novel risk factor for severe COVID-19 in non-geriatric patients.PloS one · 2022Article
- Antibody Responsiveness to Influenza: What Drives It?Viruses · 2021Review
- Immune Cell Number, Phenotype, and Function in the Elderly with Sepsis.Aging and disease · 2021Review
- Acute CMV hepatitis in an immunocompetent patient.BMJ case reports · 2020Article
- Impact of cytomegalovirus load on host response to sepsis.Medical microbiology and immunology · 2019Review
- Article
- Epidemiology and Immune Pathogenesis of Viral Sepsis.Frontiers in immunology · 2018Review
- Tissue reservoirs of antiviral T cell immunity in persistent human CMV infection.The Journal of experimental medicine · 2017Article
- Cytomegalovirus infection in immunocompetent critically ill adults: literature review.Annals of intensive care · 2016Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Human cytomegalovirus (HCMV) is an undisputed pathogen in humans with severe immune compromise, which has historically been thought to carry little consequence in immunocompetent hosts. During the past decade, however, accumulating data suggest that significant numbers of immunocompetent humans reactivate HCMV during critical illness, and that these reactivation episodes are associated with worsened outcomes. Because most people are infected with this ubiquitous virus by adulthood, confirming pathogenicity has now become a clinical priority. In this article, we will review the incidence and implications of reactivation, the relevant immune responses and reactivation triggers relevant to the immunocompetent host. We will summarize the progress made during the past ten years, outline the work ongoing in this field, and identify the major gaps remaining in our emerging understanding of this phenomenon.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.