ArticleBiochimica et biophysica acta2011
Comparative study of clinical pulmonary surfactants using atomic force microscopy.
Article in Biochimica et biophysica acta, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 125 citations in OpenAlex.
- Surface Symphony: Orchestrating DPPC/DOPC Monolayer Behavior.Microscopy research and technique · 2026Article
- The pristine unused pulmonary surfactant isolated from human amniotic fluid forms highly condensed interfacial films.Physiological reports · 2025Article
- Comparative biophysical study of clinical surfactants using constrained drop surfactometry.American journal of physiology. Lung cellular and molecular physiology · 2024Article
- The biophysical function of pulmonary surfactant.Biophysical journal · 2024Review
- Thermodynamic and Structural Study of Budesonide-Exogenous Lung Surfactant System.International journal of molecular sciences · 2024Article
- Biophysical function of pulmonary surfactant in liquid ventilation.Biophysical journal · 2023Article
- Phase transitions of the pulmonary surfactant film at the perfluorocarbon-water interface.Biophysical journal · 2023Article
- A Deeper Insight into the Interfacial Behavior and Structural Properties of Mixed DPPC/POPC Monolayers: Implications for Respiratory Health.Membranes · 2022Article
- Evaluating the Impact of Hydrophobic Silicon Dioxide in the Interfacial Properties of Lung Surfactant Films.Environmental science & technology · 2022Article
- Interfacial behavior of phospholipid monolayers revealed by mesoscopic simulation.Biophysical journal · 2021Article
- Polyhydroxyalkanoate Nanoparticles for Pulmonary Drug Delivery: Interaction with Lung Surfactant.Nanomaterials (Basel, Switzerland) · 2021Article
- The Role of Pulmonary Surfactants in the Treatment of Acute Respiratory Distress Syndrome in COVID-19.Frontiers in pharmacology · 2021Review
- Atomic Force Microscopy Imaging of Adsorbed Pulmonary Surfactant Films.Biophysical journal · 2020Article
- Graphene-based sensing of oxygen transport through pulmonary membranes.Nature communications · 2020Article
- Review
- Electronic cigarette vapor alters the lateral structure but not tensiometric properties of calf lung surfactant.Respiratory research · 2017Article
- Effect of pulmonary surfactant on the dissolution, stability and uptake of zinc oxide nanowires by human respiratory epithelial cells.Nanotoxicology · 2016Article
- Phase Transitions in Dipalmitoylphosphatidylcholine Monolayers.Langmuir : the ACS journal of surfaces and colloids · 2016Article
- Automated Droplet Manipulation Using Closed-Loop Axisymmetric Drop Shape Analysis.Langmuir : the ACS journal of surfaces and colloids · 2016Article
- The role of natural processes and surface energy of inhaled engineered nanoparticles on aggregation and corona formation.NanoImpact · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
Abstract
Clinical pulmonary surfactant is routinely used to treat premature newborns with respiratory distress syndrome, and has shown great potential in alleviating a number of neonatal and adult respiratory diseases. Despite extensive study of chemical composition, surface activity, and clinical performance of various surfactant preparations, a direct comparison of surfactant films is still lacking. In this study, we use atomic force microscopy to characterize and compare four animal-derived clinical surfactants currently used throughout the world, i.e., Survanta, Curosurf, Infasurf and BLES. These modified-natural surfactants are further compared to dipalmitoyl phosphatidylcholine (DPPC), a synthetic model surfactant of DPPC:palmitoyl-oleoyl phosphatidylglycerol (POPG) (7:3), and endogenous bovine natural surfactant. Atomic force microscopy reveals significant differences in the lateral structure and molecular organization of these surfactant preparations. These differences are discussed in terms of DPPC and cholesterol contents. We conclude that all animal-derived clinical surfactants assume a similar structure of multilayers of fluid phospholipids closely attached to an interfacial monolayer enriched in DPPC, at physiologically relevant surface pressures. This study provides the first comprehensive survey of the lateral structure of clinical surfactants at various surface pressures. It may have clinical implications on future application and development of surfactant preparations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.