ArticleClinical and experimental immunology2011
Regulatory T cells and chronic immune activation in human immunodeficiency virus 1 (HIV-1)-infected children.
Article in Clinical and experimental immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Forkhead box protein 3(+) regulatory T cells and Helios(+) subset in perinatally acquired HIV.Clinical and experimental immunology · 2015Trial
- High-frequency and activation of CD4Veterinary research · 2021Article
- The role of CD38 in HIV infection.AIDS research and therapy · 2021Review
- Long-term clinical, virological and immunological outcomes following planned treatment interruption in HIV-infected children.HIV medicine · 2021Article
- Biological Aging and Immune Senescence in Children with Perinatally Acquired HIV.Journal of immunology research · 2020Review
- Increased Regulatory T-Cell Activity and Enhanced T-Cell Homeostatic Signaling in Slow Progressing HIV-infected Children.Frontiers in immunology · 2019Article
- Immunological profile of an infant treated with integrase inhibitor from the neonatal period.Journal of virus eradication · 2019Article
- Potential Role of Regulatory T Cells in Mother-to-Child Transmission of HIV.Current HIV research · 2018Article
- Gag-Specific CD8 T-Cell Proliferation Is Associated With Higher Peripheral Blood Levels of Transforming Growth Factor-β and Gut-Homing T Cells in Youths Perinatally Infected With Human Immunodeficiency Virus-1: The ANRS-EP38-IMMIP Study.Open forum infectious diseases · 2017Article
- Impact of monotherapy on HIV-1 reservoir, immune activation, and co-infection with Epstein-Barr virus.PloS one · 2017Article
- Terminally differentiated memory T cells are increased in patients with common variable immunodeficiency and selective IgA deficiency.Central-European journal of immunology · 2017Article
- Impact of HIV Infection and Anti-Retroviral Therapy on the Immune Profile of and Microbial Translocation in HIV-Infected Children in Vietnam.International journal of molecular sciences · 2016Article
- Baseline Inflammatory Biomarkers Identify Subgroups of HIV-Infected African Children With Differing Responses to Antiretroviral Therapy.The Journal of infectious diseases · 2016Article
- Premature aging and immune senescence in HIV-infected children.AIDS (London, England) · 2016Article
- Clinical Impact of Regulatory T cells (Treg) in Cancer and HIV.Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2015Article
- Host factors and early treatments to restrict paediatric HIV infection and early disease progression.Journal of virus eradication · 2015Review
- Association between discordant immunological response to highly active anti-retroviral therapy, regulatory T cell percentage, immune cell activation and very low-level viraemia in HIV-infected patients.Clinical and experimental immunology · 2014Article
- Immunity to HIV in Early Life.Frontiers in immunology · 2014Review
- Functional characterization of HLA-G⁺ regulatory T cells in HIV-1 infection.PLoS pathogens · 2013Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The function of CD4(+) T cells with regulatory activity (T(regs)) is the down-regulation of immune responses. This suppressive activity may limit the magnitude of effector responses, resulting in failure to control human immunodeficiency virus 1 (HIV-1) infection, but may also suppress chronic immune activation, a characteristic feature of HIV-1 disease. We evaluated the correlation between viral load, immune activation and T(regs) in HIV-1-infected children. Eighty-nine HIV-1-infected children (aged 6-14 years) were included in the study and analysed for HIV-1 plasmaviraemia, HIV-1 DNA load, CD4 and CD8 cell subsets. T(reg) cells [CD4(+)CD25(high)CD127(low) forkhead box P3 (FoxP3(high))] and CD8-activated T cells (CD8(+)CD38(+)) were determined by flow cytometry. Results showed that the number of activated CD8(+)CD38(+)T cells increased in relation to HIV-1 RNA plasmaviraemia (r = 0·403, P < 0·0001). The proportion of T(regs) also correlated positively with HIV-1 plasmaviraemia (r = 0·323, P = 0·002), but correlated inversely with CD4(+) cells (r = -0·312, P = 0·004), thus suggesting a selective expansion along with increased viraemia and CD4(+) depletion. Interestingly, a positive correlation was found between the levels of T(regs) and CD8(+)CD38(+)T cells (r = 0·305, P = 0·005), and the percentage of T(regs) tended to correlate with HIV-1 DNA load (r = 0·224, P = 0·062). Overall, these findings suggest that immune activation contributes to the expansion of T(reg) cells. In turn, the suppressive activity of T(regs) may impair effector responses against HIV-1, but appears to be ineffective in limiting immune activation.
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