ArticleBiomacromolecules2011
Tunable silk: using microfluidics to fabricate silk fibers with controllable properties.
Article in Biomacromolecules, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 160 citations in OpenAlex.
- Development of Small-Diameter Silk Vascular Grafts Supported by Solid-State Nuclear Magnetic Resonance Structural Analysis.Molecules (Basel, Switzerland) · 2025Review
- Microcompartmentalization Controls Silk Feedstock Rheology.Langmuir : the ACS journal of surfaces and colloids · 2023Article
- A molecular atlas reveals the tri-sectional spinning mechanism of spider dragline silk.Nature communications · 2023Article
- Tailoring micro/nano-fibers for biomedical applications.Bioactive materials · 2023Review
- A brief review on the mechanisms and approaches of silk spinning-inspired biofabrication.Frontiers in bioengineering and biotechnology · 2023Review
- High Performance Marine and Terrestrial Bioadhesives and the Biomedical Applications They Have Inspired.Molecules (Basel, Switzerland) · 2022Review
- Bioinspired silk fibroin materials: From silk building blocks extraction and reconstruction to advanced biomedical applications.Materials today. Bio · 2022Review
- Complexity of Spider Dragline Silk.Biomacromolecules · 2022Review
- (Bio)manufactured Solutions for Treatment of Bone Defects with Emphasis on US-FDA Regulatory Science Perspective.Advanced nanobiomed research · 2022Article
- Nanofibril Alignment during Assembly Revealed by an X-ray Scattering-Based Digital Twin.ACS nano · 2022Article
- From Mesoscopic Functionalization of Silk Fibroin to Smart Fiber Devices for Textile Electronics and Photonics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Review
- Deconstruction and Reassembly of Renewable Polymers and Biocolloids into Next Generation Structured Materials.Chemical reviews · 2021Review
- Biocompatible Micron-Scale Silk Fibers Fabricated by Microfluidic Wet Spinning.Advanced healthcare materials · 2021Article
- From Protein Building Blocks to Functional Materials.ACS nano · 2021Review
- Interplay of Different Major Ampullate Spidroins during Assembly and Implications for Fiber Mechanics.Advanced materials (Deerfield Beach, Fla.) · 2021Article
- Enzyme-Mediated Conjugation of Peptides to Silk Fibroin for Facile Hydrogel Functionalization.Annals of biomedical engineering · 2020Article
- Horseradish Peroxidase-Catalyzed Crosslinking of Fibrin Microthread Scaffolds.Tissue engineering. Part C, Methods · 2020Article
- The role of microfluidics in protein formulations with pre-programmed functional characteristics.Biologics : targets & therapy · 2018Review
- Using hydrodynamic focusing to predictably alter the diameter of synthetic silk fibers.PloS one · 2018Article
- Microfluidic Dry-spinning and Characterization of Regenerated Silk Fibroin Fibers.Journal of visualized experiments : JoVE · 2017Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Despite widespread use of silk, it remains a significant challenge to fabricate fibers with properties similar to native silk. It has recently been recognized that the key to tuning silk fiber properties lies in controlling internal structure of assembled β-sheets. We report an advance in the precise control of silk fiber formation with control of properties via microfluidic solution spinning. We use an experimental approach combined with modeling to accurately predict and independently tune fiber properties including Young's modulus and diameter to customize fibers. This is the first reported microfluidic approach capable of fabricating functional fibers with predictable properties and provides new insight into the structural transformations responsible for the unique properties of silk. Unlike bulk processes, our method facilitates the rapid and inexpensive fabrication of fibers from small volumes (50 μL) that can be characterized to investigate sequence-structure-property relationships to optimize recombinant silk technology to match and exceed natural silk properties.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.