Evidence map›Paper›PMID 21438620›Full record

ArticleThe Journal of organic chemistry2011

Design and synthesis of unnatural heparosan and chondroitin building blocks.

Smritilekha Bera, Robert J Linhardt

Abstract read
In one paragraph

Article in The Journal of organic chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Article
  3. Synthesis and antimicrobial activity of 1Beilstein journal of organic chemistry · 2021
    Article
  4. Article
  5. Review
  6. Article
  7. Engineering of routes to heparin and related polysaccharides.Applied microbiology and biotechnology · 2012
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Smritilekha BeraDepartment of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York 12180, USA.
Robert J Linhardt
Rensselaer Polytechnic Institute · US

Funding

In vitro synthesis of recombinant heparan sulfateR01HL094463 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LIU, JIAN, PAWLINSKI, RAFAL L · 2009 to 2021
$5.2M
Synthetic Heparan Sulfate: Probing Biosynthesis to Prepare Defined DrugsR01HL062244 · NHLBI · UNIVERSITY OF IOWA · PI DEANGELIS, PAUL L, LINHARDT, ROBERT J · 2001 to 2016
$4.1M
Stable Carbohydrate Libraries in Infectious DiseaseR01AI065786 · NIAID · RENSSELAER POLYTECHNIC INSTITUTE · PI LINHARDT, ROBERT J · 2007 to 2011
$1.9M
NHLBI NIH HHS HL094463NHLBI NIH HHS HL62244NHLBI NIH HHS R01 HL062244NHLBI NIH HHS R01 HL094463NIAID NIH HHS AI065786NIAID NIH HHS R01 AI065786
6 · The paper itself

Abstract

Triazole linked heparosan and chondroitin disaccharide and tetrasaccharide building blocks were synthesized in a stereoselective manner by applying a very efficient copper catalyzed azide-alkyne cycloaddition (CuAAC) reaction of appropriately substituted azido-glucuronic acid and propargyluted N-acetyl glucosamine and N-acetyl galactosamine derivative, respectively. The resulting suitably substituted tetrasaccharide analogues can be easily converted into azide and alkyne unit for further synthesis of higher oligosaccharide analogues.

Indexed as

Drug DesignAcetylglucosamineAzidesChondroitinDisaccharidesHeparan SulfateStereoisomerismSulfatesAcetylglucosamineAzidesChondroitinDisaccharidesHeparan SulfateheparosanSulfates

Identifiers

PMID21438620
PMCPMC3092388
OpenAlexW2016634472

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.