ReviewThe Journal of organic chemistry2011
Natural products synthesis: enabling tools to penetrate Nature's secrets of biogenesis and biomechanism.
Review in The Journal of organic chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed.
- Total Synthesis of (+)-Malbrancheamide B Employing a Bioinspired Strategy.Organic letters · 2026Article
- Late-Stage Diversification of Natural Products.ACS central science · 2020Review
- Bioinspired chemical synthesis of monomeric and dimeric stephacidin A congeners.Nature chemistry · 2018Article
- Further Investigation of the Intermolecular Diels-Alder Cycloaddition for the Synthesis of Bicyclo[2.2.2]diazaoctane Alkaloids.The Journal of organic chemistry · 2017Article
- Intermolecular Diels-Alder Cycloaddition for the Construction of Bicyclo[2.2.2]diazaoctane Structures: Formal Synthesis of Brevianamide B and Premalbrancheamide.The Journal of organic chemistry · 2016Article
- Adaptation of a small-molecule hydrogen-bond donor catalyst to an enantioselective hetero-Diels-Alder reaction hypothesized for brevianamide biosynthesis.Organic letters · 2015Article
- Enantiomeric natural products: occurrence and biogenesis.Angewandte Chemie (International ed. in English) · 2012Review
- Phylogeny and nomenclature of the genus Talaromyces and taxa accommodated in Penicillium subgenus Biverticillium.Studies in mycology · 2011Article
- Lessons and revelations from biomimetic syntheses.Nature chemical biology · 2011Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Selected examples from our laboratory of how synthetic technology platforms developed for the total synthesis of several disparate families of natural products was harnessed to penetrate biomechanistic and/or biosynthetic queries is discussed. Unexpected discoveries of biomechanistic reactivity and/or penetrating the biogenesis of naturally occurring substances were made possible through access to substances available only through chemical synthesis. Hypothesis-driven total synthesis programs are emerging as very useful conceptual templates for penetrating and exploiting the inherent reactivity of biologically active natural substances. In many instances, new enabling synthetic technologies were required to be developed. The examples demonstrate the often untapped richness of complex molecule synthesis to provide powerful tools to understand, manipulate and exploit Nature's vast and creative palette of secondary metabolites.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.