ArticleAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics2011
Absence of association between specific common variants of the obesity-related FTO gene and psychological and behavioral eating disorder phenotypes.
Article in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Trial
- Association between impulsivity traits and body mass index at the observational and genetic epidemiology level.Scientific reports · 2019Observational
- Genetic risk factors for eating disorders: an update and insights into pathophysiology.Therapeutic advances in psychopharmacology · 2019Review
- The Anorexia Nervosa Genetics Initiative (ANGI): Overview and methods.Contemporary clinical trials · 2018Article
- Influence ofDiabetes, metabolic syndrome and obesity : targets and therapy · 2018Article
- FTO associations with obesity and telomere length.Journal of biomedical science · 2017Review
- Overlap in Eating Disorders and Obesity in Adolescence.Current diabetes reports · 2015Review
- Dietary Intake, FTO Genetic Variants, and Adiposity: A Combined Analysis of Over 16,000 Children and Adolescents.Diabetes · 2015Article
- The 'Fat Mass and Obesity Related' (FTO) gene: Mechanisms of Impact on Obesity and Energy Balance.Current obesity reports · 2015Review
- FTO genetic variants, dietary intake and body mass index: insights from 177,330 individuals.Human molecular genetics · 2014Article
- Risk factors across the eating disorders.Psychiatry research · 2014Article
- Genetics of eating disorders.Current psychiatry reports · 2013Review
- Sex differences in the physiology of eating.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Review
- The genetics of childhood obesity and interaction with dietary macronutrients.Genes & nutrition · 2013Article
- Genetics and Epigenetics of Eating Disorders.Advances in genomics and geneticsArticle
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Authors and funding
25 authors at 20 institutions in 6 countries.
Funding
Abstract
Extensive population-based genome-wide association studies have identified an association between the FTO gene and BMI; however, the mechanism of action is still unknown. To determine whether FTO may influence weight regulation through psychological and behavioral factors, seven single-nucleotide polymorphisms (SNPs) of the FTO gene were genotyped in 1,085 individuals with anorexia nervosa (AN) and 677 healthy weight controls from the international Price Foundation Genetic Studies of Eating Disorders. Each SNP was tested in association with eating disorder phenotypes and measures that have previously been associated with eating behavior pathology: trait anxiety, harm-avoidance, novelty seeking, impulsivity, obsessionality, compulsivity, and concern over mistakes. After appropriate correction for multiple comparisons, no significant associations between individual FTO gene SNPs and eating disorder phenotypes or related eating behavior pathology were identified in cases or controls. Thus, this study found no evidence that FTO gene variants associated with weight regulation in the general population are associated with eating disorder phenotypes in AN participants or matched controls.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.