ArticleJournal of clinical laboratory analysis2011
Increased level of serum Homocysteine in vitiligo.
Article in Journal of clinical laboratory analysis, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Risk factors for cardiovascular diseases in patients with vitiligo: an analysis of current evidence.Annals of medicine · 2024Pooled it
- Markers of Systemic Metabolic Dysfunction in Vitiligo and Their Potential Role in Disease Pathogenesis: A Narrative Review.Health science reports · 2026Article
- Markers of Metabolic Abnormalities in Vitiligo Patients.International journal of molecular sciences · 2024Article
- Vitiligo and insulin resistance as a component of metabolic syndrome: an analysis.Postepy dermatologii i alergologii · 2023Review
- Where Microneedle Meets Biomarkers: Futuristic Application for Diagnosing and Monitoring Localized External Organ Diseases.Advanced healthcare materials · 2023Review
- Article
- Metabolic Basis and Clinical Evidence for Skin Lightening Effects of Thiol Compounds.Antioxidants (Basel, Switzerland) · 2022Review
- Clinical Features, Immunopathogenesis, and Therapeutic Strategies in Vitiligo.Clinical reviews in allergy & immunology · 2021Review
- Metabolomic signature of amino acids in plasma of patients with non-segmental Vitiligo.Metabolomics : Official journal of the Metabolomic Society · 2021Article
- Vitiligo: The Association With Metabolic Syndrome and the Role of Simvastatin as an Immunomodulator.Cureus · 2021Review
- The effect of narrowband ultraviolet B phototherapy on serum folate level.Caspian journal of internal medicine · 2021Article
- Urinary metabolomic investigations in vitiligo patients.Scientific reports · 2020Article
- Influence of MTHFR gene variations on perceived stress modification: Preliminary results of NURSE study.Medical journal of the Islamic Republic of Iran · 2017Article
- Stability in Vitiligo: Is there a Perfect Way to Predict it?Journal of cutaneous and aesthetic surgery · 2013Review
- Serum Homocysteine and Total Antioxidant Status in Vitiligo: A Case Control Study in Indian Population.Indian journal of dermatologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVitiligo is an acquired depigmenting disorder caused by the destruction of melanocytes. The exact etiopathogenesis and mechanisms of vitiligo are not fully understood. Vitamin B12 and folic acid levels are decreased in vitiligo, which are the important cofactors required in the metabolism of Homocysteine (Hcy). Consequently, Hcy level increases in the circulation. Therefore, it is possible that increased Hcy plays a role in melanocytes destruction. The aim was to study for any association of vitiligo with serum Hcy level.
methodA total of 30 vitiligo patients of both sexes and 30 control subjects were enrolled in this study. Sera from patients and controls were assayed for Hcy by Enzyme immunoassay. The collected data were analyzed by SPSS version-16.
resultsThe mean serum level of Hcy was significantly higher in patients with vitiligo as compared with healthy controls and its level was high in male patients as compared with female patients. The Hcy level in vegetarian patients was significantly higher as compared with nonvegetarian patients. The Hcy level was also significantly higher in active vitiligo patients as compared with stable vitiligo patients.
conclusionAn increased serum Hcy may be a precipitating factor for vitiligo in the predisposed individuals. Serum Hcy is related to the gender of patients, activity of disease, and dietary habits of vitiligo patients.
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Registered trials
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