ArticleCellular and molecular life sciences : CMLS2011
Autophagic activity in cortical neurons under acute oxidative stress directly contributes to cell death.
Article in Cellular and molecular life sciences : CMLS, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- The Molecular Mechanisms of Neuroinflammation in Alzheimer's Disease, the Consequence of Neural Cell Death.International journal of molecular sciences · 2023Review
- The Interaction of Aging and Cellular Stress Contributes to Pathogenesis in Mouse and Human Huntington Disease Neurons.Frontiers in aging neuroscience · 2020Article
- Huangqi-Danshen decoction alleviates diabetic nephropathy inAmerican journal of translational research · 2020Article
- Autophagy as a Homeostatic Mechanism in Response to Stress Conditions in the Central Nervous System.Molecular neurobiology · 2019Review
- Glycogen synthase protects neurons from cytotoxicity of mutant huntingtin by enhancing the autophagy flux.Cell death & disease · 2018Article
- Trehalose Activates Autophagy and Prevents Hydrogen Peroxide-Induced Apoptosis in the Bone Marrow Stromal Cells.Iranian journal of pharmaceutical research : IJPR · 2018Article
- L-Ascorbate Protects Against Methamphetamine-Induced Neurotoxicity of Cortical Cells via Inhibiting Oxidative Stress, Autophagy, and Apoptosis.Molecular neurobiology · 2017Article
- The Ketone Body, β-Hydroxybutyrate Stimulates the Autophagic Flux and Prevents Neuronal Death Induced by Glucose Deprivation in Cortical Cultured Neurons.Neurochemical research · 2016Article
- Andrographolide inhibits growth of human T-cell acute lymphoblastic leukemia Jurkat cells by downregulation of PI3K/AKT and upregulation of p38 MAPK pathways.Drug design, development and therapy · 2016Article
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- Mitochondrial dysfunction induced by a post-translationally modified amyloid linked to a familial mutation in an alternative model of neurodegeneration.Biochimica et biophysica acta · 2014Article
- Inhibition of autophagy via activation of PI3K/Akt pathway contributes to the protection of ginsenoside Rb1 against neuronal death caused by ischemic insults.International journal of molecular sciences · 2014Article
- Rapamycin and interleukin-1β impair brain-derived neurotrophic factor-dependent neuron survival by modulating autophagy.The Journal of biological chemistry · 2014Article
- Mitochondrial dysfunction and mitophagy: the beginning and end to diabetic nephropathy?British journal of pharmacology · 2014Review
- N-acetyl-serotonin offers neuroprotection through inhibiting mitochondrial death pathways and autophagic activation in experimental models of ischemic injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
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- Defective autophagy in Parkinson's disease: role of oxidative stress.Molecular neurobiology · 2012Review
- Erythropoietin modulates autophagy signaling in the developing rat brain in an in vivo model of oxygen-toxicity.International journal of molecular sciences · 2012Article
- Gene-specific differential response to anti-apoptotic therapies in zebrafish models of ocular coloboma.Molecular vision · 2011Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Primary neurons undergo insult-dependent programmed cell death. We examined autophagy as a process contributing to cell death in cortical neurons after treatment with either hydrogen peroxide (H(2)O(2)) or staurosporine. Although caspase-9 activation and cleavage of procaspase-3 were significant following staurosporine treatment, neither was observed following H(2)O(2) treatment, indicating a non-apoptotic death. Autophagic activity increased rapidly with H(2)O(2), but slowly with staurosporine, as quantified by processing of endogenous LC3. Autophagic induction by both stressors increased the abundance of fluorescent puncta formed by GFP-LC3, which could be blocked by 3-methyladenine. Significantly, such inhibition of autophagy blocked cell death induced by H(2)O(2) but not staurosporine. Suppression of Atg7 inhibited cell death by H(2)O(2), but not staurosporine, whereas suppression of Beclin 1 prevented cell death by both treatments, suggesting it has a complex role regulating both apoptosis and autophagy. We conclude that autophagic mechanisms are activated in an insult-dependent manner and that H(2)O(2) induces autophagic cell death.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.