Trial reportEuropean journal of applied physiology2011
Oral tyrosine supplementation improves exercise capacity in the heat.
Trial report in European journal of applied physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Pooled it
- The Effect of Dietary Supplements on Endurance Exercise Performance and Core Temperature in Hot Environments: A Meta-analysis and Meta-regression.Sports medicine (Auckland, N.Z.) · 2021Pooled it
- Exercise-induced stress behavior, gut-microbiota-brain axis and diet: a systematic review for athletes.Journal of the International Society of Sports Nutrition · 2016Pooled it
- Effects of L-Tyrosine Ingestion on Endurance Performance in Mentally Fatigued Cyclists.European journal of sport science · 2026Trial
- Pre-workout multi-ingredients or carbohydrate alone promote similar resistance training outcomes in middle-aged adults: a double-blind, randomized controlled trial.Journal of the International Society of Sports Nutrition · 2025Trial
- Trial
- Acute oral administration of a tyrosine and phenylalanine-free amino acid mixture reduces exercise capacity in the heat.European journal of applied physiology · 2013Trial
- Plant-protein supplementation improves thermoregulatory responses and ameliorates markers of intestinal damage during exercise in the heat.Experimental physiology · 2026Article
- Advanced periovulatory follicle progression in beef heifers: association with higher estrous-associated temperatures and estrous activity on intrafollicular levels of estradiol and metabolites.Journal of animal science · 2026Article
- Skeletal muscle mitochondrial-methylation-neurotransmitter crosstalk: a novel synergistic model of betaine, tyrosine, and Cordyceps for exercise performance in older adults, individuals with metabolic disorders, and healthy populations.Frontiers in nutrition · 2026Review
- Review
- Acute effects of multi-ingredient pre-workout dietary supplement on anaerobic performance in untrained men: a randomized, crossover, single blind study.BMC sports science, medicine & rehabilitation · 2024Article
- Association of phenylalanine and tyrosine metabolism with mortality and response to nutritional support among patients at nutritional risk: a secondary analysis of the randomized clinical trial EFFORT.Frontiers in nutrition · 2024Article
- Unraveling athletic performance: Transcriptomics and external load monitoring in handball competition.PloS one · 2024Article
- 3'sialyllactose and 6'sialyllactose enhance performance in endurance-type exercise through metabolic adaptation.Food science & nutrition · 2023Article
- The effectiveness of heat preparation and alleviation strategies for cognitive performance: A systematic review.Temperature (Austin, Tex.) · 2023Review
- Article
- Sweat analysis with a wearable sensing platform based on laser-induced graphene.APL bioengineering · 2022Article
- Serum Amino Acid Profile Changes After Repetitive Breath-Hold Dives: A Preliminary Study.Sports medicine - open · 2022Article
- Metabolomics of Endurance Capacity in World Tour Professional Cyclists.Frontiers in physiology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increased brain dopamine availability improves prolonged exercise tolerance in the heat. It is unclear whether supplementing the amino-acid precursor of dopamine increases exercise capacity in the heat. Eight healthy male volunteers [mean age 32 ± 11 (SD) years; body mass 75.3 ± 8.1 kg; peak oxygen uptake ([Formula: see text]) 3.5 ± 0.3 L min(-1)] performed two exercise trials separated by at least 7 days in a randomised, crossover design. Subjects consumed 500 mL of a flavoured sugar-free drink (PLA), or the same drink with 150 mg kg body mass(-1) tyrosine (TYR) in a double-blind manner 1 h before cycling to exhaustion at a constant exercise intensity equivalent to 68 ± 5% [Formula: see text] in 30°C and 60% relative humidity. Pre-exercise plasma tyrosine:large neutral amino acids increased 2.9-fold in TYR (P < 0.01), while there was no change in PLA (P > 0.05). Subjects cycled longer in TYR compared to PLA (80.3 ± 19.7 min vs. 69.2 ± 14.0 min; P < 0.01). Core temperature, mean weighted skin temperature, heart rate, ratings of perceived exertion and thermal sensation were similar in TYR and PLA during exercise and at exhaustion (P > 0.05) despite longer exercise time in TYR. The results show that acute tyrosine supplementation is associated with increased endurance capacity in the heat in moderately trained subjects. The results also suggest for the first time that the availability of tyrosine, a nutritional dopamine precursor, can influence the ability to subjectively tolerate prolonged submaximal constant-load exercise in the heat.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.