ArticleInternal and emergency medicine2012
Primary resistance of Helicobacter pylori to levofloxacin and moxifloxacine in Iran.
Article in Internal and emergency medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- The prevalence of clarithromycin-resistantPeerJ · 2023Pooled it
- Pooled it
- Identification of plasmid-mediated quinolone resistance genes inIranian journal of microbiology · 2026Article
- Antibiotic Resistance Identification Among the Patients withMiddle East journal of digestive diseases · 2025Article
- Reevaluation of the Efficacy of First Line Regimen forClinical and experimental gastroenterology · 2020Article
- High Prevalence of Antibiotic Resistance in IranianJournal of clinical medicine · 2019Article
- Antibacterial activity of lactobacilli probiotics on clinical strains ofIranian journal of basic medical sciences · 2019Article
- Comparison of Levofloxacin-Based, 10-day Sequential Therapy with 14-day Quadruple Therapy forMiddle East journal of digestive diseases · 2018Article
- Eradication ofMiddle East journal of digestive diseases · 2018Review
- Multicenter Study of Antibiotic Resistance Profile of H. pylori and Distribution of CYP2C19 Gene Polymorphism in Rural Population of Chongqing, China.Gastroenterology research and practice · 2016Article
- Prevalence of antibiotic resistance in Helicobacter pylori: A recent literature review.World journal of methodology · 2015Review
- How to Effectively Use Bismuth Quadruple Therapy: The Good, the Bad, and the Ugly.Gastroenterology clinics of North America · 2015Review
- Clarithromycin vs. Gemifloxacin in Quadruple Therapy Regimens for Empiric Primary Treatment of Helicobacter pylori Infection: A Randomized Clinical Trial.Middle East journal of digestive diseases · 2015Article
- Helicobacter pylori in Iran: A systematic review on the antibiotic resistance.Iranian journal of basic medical sciences · 2015Review
- Comparison of quadruple and triple Furazolidone containing regimens on eradication of helicobacter pylori.Medical journal of the Islamic Republic of Iran · 2015Article
- Novel Idea: Virulence-Based Therapy Against Helicobacter pylori Infection (Smart Therapy).Frontiers in medicine · 2014Review
- Therapy of Helicobacter pylori: present medley and future prospective.BioMed research international · 2014Review
- Prevalence of horB gene among the Helicobacter pylori strains isolated from dyspeptic patients: first report from Iran.Internal and emergency medicine · 2012Article
- Variability in Prevalence of Helicobacter pylori Strains Resistant to Clarithromycin and Levofloxacin in Southern Poland.Gastroenterology research and practice · 2012Article
- Call for global vaccine instead of Helicobacter pylori blind antibiotic therapy.Annals of African medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The increase in the prevalence of antibiotic resistance in Helicobacter pylori had a drastic effect on successful treatment. Up-to-date information on H. pylori antibiotic therapy in Iran is still limited. In this study, we aim to determine the prevalence of antibiotic resistance among the H. pylori strains. Furthermore, the possibility of using fluoroquinolones for antibiotic treatment was investigated. Antral biopsy specimens obtained from dyspeptic patients were investigated for H. pylori. Bacterial culture and susceptibility tests were done based on standard methods. H. pylori ATCC 43504 was used as a quality control. In the current study, 30 H. pylori strains were selected randomly and retested to confirm our susceptibility tests. Of 170 patients, 150 were identified as positive for H. pylori (88.2%). In this study, 150 single colonies of H. pylori strains [81 women (54%), 69 men (46%); mean age 38.6; aged 21-70 years] were collected. Primary resistance of H. pylori isolates were clarithromycin (34%), metronidazole (78.6%), tetracycline (9.3%), amoxicillin (10%), levofloxacin (5.3%) and moxifloxacine (4.6%). In conclusion, our results show that we are confronting a new generation of resistant strains of H. pylori in Iran. This alarming finding indicates an urgent need for introduction of new effective antibiotics in our country. Since the majority of clinicians prefer to continue with the ineffective antibiotics as therapeutic regimens, they must also be prepared to deal with treatment failures.
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Registered trials
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