ArticleThe journal of nutrition, health & aging2011
Prohepcidin and iron metabolism parameters in the obese elderly patients with anemia.
Article in The journal of nutrition, health & aging, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Acupuncture Improves Intestinal Absorption of Iron in Iron-deficient Obese Patients: A Randomized Controlled Preliminary Trial.Chinese medical journal · 2017Trial
- Obesity and iron-deficiency anemia in women of reproductive age in northern Iran.Journal of education and health promotion · 2019Article
- Editorial: Anemia of Old Age.The journal of nutrition, health & aging · 2019Article
- The impact of obesity and insulin resistance on iron and red blood cell parameters: a single center, cross-sectional study.Turkish journal of haematology : official journal of Turkish Society of Haematology · 2014Article
- Impaired iron status in aging research.International journal of molecular sciences · 2012Review
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6 authors.
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Abstract
objectiveTo examine the impact of a body fat content on the concentration of a serum prohepcidin, iron metabolism parameters and inflammation markers in elderly patients with microcytic or normocytic anemia.
designClinical study with biochemical and anthropometric measurements. SUBJECTS: Fifty two elderly patients (19 male, 33 female) with anemia, 65-91 years of age. MEASUREMENTS: Prohepcidin, ferritin, soluble transferrin receptor, erythropoietin and interleukin-6 were measured using commercially available ELISA kits. Iron, TIBC, transferrin, C-reactive protein and complete blood count were assayed using standard laboratory methods. Body fat content, fat distribution and protein nutrition state parameters were assessed by means of anthropometry.
resultsMean serum prohepcidin levels were significantly higher in patients with high body fat content in comparison to patients with normal body fat content (224,85 vs 176,6 ng/ml). Prohepcidin levels of the elderly patients with anemia were positively correlated with biceps, subscapular and suprailiac skinfold thickness or body fat mass percentage. In our study serum prohepcidin levels do not correlate with any iron parameters or inflammation markers.
conclusionSumming up, the results of this study indicate that increased prohepcidin concentration, observed in obese elderly patients with anemia, may play an important role in iron deficiency development.
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