ArticleClinics (Sao Paulo, Brazil)2011
Gynura procumbens Merr. decreases blood pressure in rats by vasodilatation via inhibition of calcium channels.
Article in Clinics (Sao Paulo, Brazil), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 49 citations in OpenAlex.
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- Review of Natural Resources With Vasodilation: Traditional Medicinal Plants, Natural Products, and Their Mechanism and Clinical Efficacy.Frontiers in pharmacology · 2021Review
- Vasorelaxant activities and the underlying pharmacological mechanisms of Gynura procumbens Merr. leaf extracts on rat thoracic aorta.Inflammopharmacology · 2019Article
- Pharmacological Studies Pertaining to Smooth Muscle Relaxant, Platelet Aggregation Inhibitory and Hypotensive Effects ofEvidence-based complementary and alternative medicine : eCAM · 2019Article
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- Vasorelaxant and Hypotensive Effects of Cheonwangbosimdan in SD and SHR Rats.Evidence-based complementary and alternative medicine : eCAM · 2018Article
- Vasorelaxant effects of Angelica decursiva root on isolated rat aortic rings.BMC complementary and alternative medicine · 2017Article
- First Report ofBioMed research international · 2016Article
- Anti-Hypertensive Herbs and Their Mechanisms of Action: Part II.Frontiers in pharmacology · 2016Review
- Gynura procumbens: An Overview of the Biological Activities.Frontiers in pharmacology · 2016Review
- Calcium intake and hypertension among obese adults in United States: associations and implications explored.Journal of human hypertension · 2015Article
- Antihyperglycaemic and Toxicological Evaluations of Extract and Fractions of Gynura procumbens Leaves.Tropical life sciences research · 2014Article
- Potassium channel openers and prostacyclin play a crucial role in mediating the vasorelaxant activity of Gynura procumbens.BMC complementary and alternative medicine · 2013Article
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5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
introductionGynura procumbens has been shown to decrease blood pressure via inhibition of the angiotensinconverting enzyme. However, other mechanisms that may contribute to the hypotensive effect have not been studied.
objectivesTo investigate the cardiovascular effects of a butanolic fraction of Gynura procumbens in rats.
methodsAnaesthetized rats were given intravenous bolus injections of butanolic fraction at doses of 2.5-20 mg/kg in vivo. The effect of butanolic fraction on vascular reactivity was recorded in isolated rat aortic rings in vitro.
resultsIntravenous administrations of butanolic fraction elicited significant (p < 0.001) and dose-dependent decreases in the mean arterial pressure. However, a significant (p < 0.05) decrease in the heart rate was observed only at the higher doses (10 and 20 mg/kg). In isolated preparations of rat aortic rings, phenylephrine (1 × 10⁻⁶ M)- or potassium chloride (8 × 10⁻² M)-precontracted endothelium-intact and -denuded tissue; butanolic fraction (1 × 10⁻⁶ - 1 × 10⁻¹ g/ml) induced similar concentration-dependent relaxation of the vessels. In the presence of 2.5 × 10⁻³ and 5.0 × 10⁻³ g/ml butanolic fraction, the contractions induced by phenylephrine (1 × 10⁻⁹-3 × 10⁻⁵ M) and potassium chloride (1 × 10⁻² - 8 × 10⁻² M) were significantly antagonized. The calcium-induced vasocontractions (1 × 10⁻⁴-1 × 10⁻²M) were antagonized by butanolic fraction concentration-dependently in calcium-free and high potassium (6×10⁻² M) medium, as well as in calcium- and potassium-free medium containing 1×10⁻⁶ M phenylephrine. However, the contractions induced by noradrenaline (1 × 10⁻⁶ M) and caffeine (4.5 × 10⁻² M) were not affected by butanolic fraction.
conclusionButanolic fraction contains putative hypotensive compounds that appear to inhibit calcium influx via receptor-operated and/or voltage-dependent calcium channels to cause vasodilation and a consequent fall in blood pressure.
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