ArticleClinics (Sao Paulo, Brazil)2011
Protective effect of sildenafil citrate on contralateral testis injury after unilateral testicular torsion/detorsion.
Article in Clinics (Sao Paulo, Brazil), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- Pathophysiology and management of testicular ischemia/reperfusion injury: Lessons from animal models.Heliyon · 2024Review
- Ameliorative effect of hesperidin against high dose sildenafil-induced liver and testicular oxidative stress and altered gene expression in male rats.Laboratory animal research · 2023Article
- Combined melatonin-adipose derived mesenchymal stem cells therapy effectively protected the testis from testicular torsion-induced ischemia-reperfusion injury.Stem cell research & therapy · 2021Article
- Effect of unilateral testicular torsion on contralateral testis in a rat model.Pediatric surgery international · 2020Article
- Clinical evaluation of testicular torsion presenting with acute abdominal pain in young males.Asian journal of urology · 2019Article
- Rapamycin protects testes against germ cell apoptosis and oxidative stress induced by testicular ischemia-reperfusion.Iranian journal of basic medical sciences · 2017Article
- Erythropoietin and sildenafil protect against ischemia/reperfusion injury following testicular torsion in adult rats.Experimental and therapeutic medicine · 2017Article
- Ginkgo Biloba Ameliorates Subfertility Induced by Testicular Ischemia/Reperfusion Injury in Adult Wistar Rats: A Possible New Mitochondrial Mechanism.Oxidative medicine and cellular longevity · 2016Article
- Organ-Protective Effects of Red Wine Extract, Resveratrol, in Oxidative Stress-Mediated Reperfusion Injury.Oxidative medicine and cellular longevity · 2015Review
- The protective effect of goji berry extract in ischemic reperfusion in testis torsion.International journal of clinical and experimental medicine · 2015Article
- Mechanisms of testicular torsion and potential protective agents.Nature reviews. Urology · 2014Review
- Comparison of erythropoietin and sildenafil protective role against ischemia/reperfusion injury of the testis in adult rats.International urology and nephrology · 2014Article
- Sildenafil Ameliorates Gentamicin-Induced Nephrotoxicity in Rats: Role of iNOS and eNOS.Journal of toxicology · 2014Article
- Beneficial effects of taurine and carnosine in experimental ischemia/reperfusion injury in testis.Pediatric surgery international · 2012Article
- Efficacy of vitamin E and selenium for the prevention of intra-abdominal adhesions in rats: uterine horn models.Clinics (Sao Paulo, Brazil) · 2011Article
- Protective effects of Tadalafil and darbepoetin against ischemia - reperfusion injury in a rat testicular torsion model.International braz j urol : official journal of the Brazilian Society of UrologyArticle
- Oxidant and antioxidant status in experimental rat testis after testicular torsion/detorsion.International journal of fertility & sterilityArticle
- The protective effect of L-arginine, tadalafil, and their combination in rat testes after ischemia and reperfusion injury.Canadian Urological Association journal = Journal de l'Association des urologues du CanadaArticle
- The biochemical effects of ischemia-reperfusion injury in the ipsilateral and contralateral testes of rats and the protective role of melatonin.Asian journal of andrologyArticle
- Comparison of quercetin and resveratrol in the prevention of injury due to testicular torsion/detorsion in rats.Asian journal of andrologyArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study was designed to investigate prevention of contralateral testicular injury with sildenafil citrate after unilateral testicular torsion/detorsion.
methodsThirty-seven adult male rats were divided into four groups: sham operated (group 1, n = 7), torsion/detorsion + saline (group 2, n = 10), torsion/detorsion + 0.7 mg of sildenafil citrate (group 3, n = 10) and torsion/detorsion + 1.4 mg of sildenafil citrate (group 4, n = 10). Unilateral testicular torsion was created by rotating the right testis 720º in a clockwise direction for 2 h in other groups, except for group 1, which was served as sham group. After torsion (2 h) and detorsion (2 h) periods, rats were killed.
resultsThe level of reduced glutathion (GSH) (p < 0.05) and the activities of catalase (p < 0.01) and glutathione peroxidase (p < 0.05) in the contralateral testis from group 2 were significantly lower and nitric oxide (NO) (p < 0.05) level in the contralateral testis were significantly higher than those of group 1. Administration of low-dose sildenafil citrate (group 3) prevented the increases in malondialdehyde and NO levels and decreases in glutathione peroxidase activities and GSH values induced by testicular torsion. However, administration of high-dose sildenafil citrate (group 4) had no effect on these testicular parameters (p > 0.05). Histopathological changes were detected in groups 2, 3 and 4.
conclusionThese results suggest that biochemically and histologically torsion/detorsion injury occurs in the contralateral testis following 2-h torsion and 2-h detorsion and that administration of low-dose sildenafil citrate before detorsion prevents ischemia/reperfusion cellular damage in testicular tissue.
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