ArticleIntegrative biology : quantitative biosciences from nano to macro2011
In search of the Golden Fleece: unraveling principles of morphogenesis by studying the integrative biology of skin appendages.
Article in Integrative biology : quantitative biosciences from nano to macro, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- Hierarchical Gene Cluster Regulation Across Vertebrate Skins: Developmental Control of Keratin Gene Expression.bioRxiv : the preprint server for biology · 2026Article
- Embryonic Avian Skin Explant Cultures: A Versatile Model for Investigating Tissue Patterning Mechanisms.The Journal of investigative dermatology · 2025Review
- Organizational principles of integumentary organs: Maximizing variations for effective adaptation.Developmental biology · 2025Review
- Skin regional specification and higher-orderScience advances · 2025Article
- A chromosome-level genome assembly of the Asian house martin implies potential genes associated with the feathered-foot trait.G3 (Bethesda, Md.) · 2024Article
- 3D skin models in domestic animals.Veterinary research · 2021Review
- Pigeon foot feathering reveals conserved limb identity networks.Developmental biology · 2019Article
- Transcriptome analyses of reprogrammed feather / scale chimeric explants revealed co-expressed epithelial gene networks during organ specification.BMC genomics · 2018Article
- Multiple Regulatory Modules Are Required for Scale-to-Feather Conversion.Molecular biology and evolution · 2018Article
- Flight feather development: its early specialization during embryogenesis.Zoological letters · 2018Article
- Genomic determinants of epidermal appendage patterning and structure in domestic birds.Developmental biology · 2017Article
- After Skin Wounding, Noncoding dsRNA Coordinates Prostaglandins and Wnts to Promote Regeneration.The Journal of investigative dermatology · 2017Article
- Heterogeneity and Developmental Connections between Cell Types Inhabiting Teeth.Frontiers in physiology · 2017Review
- A Complex Structural Variation on Chromosome 27 Leads to the Ectopic Expression of HOXB8 and the Muffs and Beard Phenotype in Chickens.PLoS genetics · 2016Article
- Molecular shifts in limb identity underlie development of feathered feet in two domestic avian species.eLife · 2016Article
- Emergence of differentially regulated pathways associated with the development of regional specificity in chicken skin.BMC genomics · 2015Article
- Predicting the spatiotemporal dynamics of hair follicle patterns in the developing mouse.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Beyond the niche: tissue-level coordination of stem cell dynamics.Annual review of cell and developmental biology · 2013Review
- Multi-layered environmental regulation on the homeostasis of stem cells: the saga of hair growth and alopecia.Journal of dermatological science · 2012Review
- Roles of EphB3/ephrin-B1 in feather morphogenesis.The International journal of developmental biology · 2012Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
The mythological story of the Golden Fleece symbolizes the magical regenerative power of skin appendages. Similar to the adventurous pursuit of the Golden Fleece by the multi-talented Argonauts, today we also need an integrated multi-disciplined approach to understand the cellular and molecular processes during development, regeneration and evolution of skin appendages. To this end, we have explored several aspects of skin appendage biology that contribute to the Turing activator/inhibitor model in feather pattern formation, the topo-biological arrangement of stem cells in organ shape determination, the macro-environmental regulation of stem cells in regenerative hair waves, and potential novel molecular pathways in the morphological evolution of feathers. Here we show our current integrative biology efforts to unravel the complex cellular behavior in patterning stem cells and the control of regional specificity in skin appendages. We use feather/scale tissue recombination to demonstrate the timing control of competence and inducibility. Feathers from different body regions are used to study skin regional specificity. Bioinformatic analyses of transcriptome microarrays show the potential involvement of candidate molecular pathways. We further show Hox genes exhibit some region specific expression patterns. To visualize real time events, we applied time-lapse movies, confocal microscopy and multiphoton microscopy to analyze the morphogenesis of cultured embryonic chicken skin explants. These modern imaging technologies reveal unexpectedly complex cellular flow and organization of extracellular matrix molecules in three dimensions. While these approaches are in preliminary stages, this perspective highlights the challenges we face and new integrative tools we will use. Future work will follow these leads to develop a systems biology view and understanding in the morphogenetic principles that govern the development and regeneration of ectodermal organs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.