ArticlePloS one2011
Both size and GC-content of minimal introns are selected in human populations.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
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- Lineage-associated Human Divergently-paired Genes Exhibit Structural and Regulatory Characteristics.Genomics, proteomics & bioinformatics · 2025Article
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- On the relation of gene essentiality to intron structure: a computational and deep learning approach.Life science alliance · 2021Article
- Precision Medicine: What Do We Expect in the Scope of Basic Biomedical Sciences?Genomics, proteomics & bioinformatics · 2016Article
- Identification and Validation of Evolutionarily Conserved Unusually Short Pre-mRNA Introns in the Human Genome.International journal of molecular sciences · 2015Article
- Intron evolution in Neurospora: the role of mutational bias and selection.Genome research · 2015Article
- Ribogenomics: the science and knowledge of RNA.Genomics, proteomics & bioinformatics · 2014Article
- Length and GC content variability of introns among teleostean genomes in the light of the metabolic rate hypothesis.PloS one · 2014Article
- Stabilizing selection, purifying selection, and mutational bias in finite populations.Genetics · 2013Article
- Does the genetic code have a eukaryotic origin?Genomics, proteomics & bioinformatics · 2013Article
- Intron retention in the alternatively spliced region of RON results from weak 3' splice site recognition.PloS one · 2013Article
- Strong mutational bias toward deletions in the Drosophila melanogaster genome is compensated by selection.Genome biology and evolution · 2013Article
- The pendulum model for genome compositional dynamics: from the four nucleotides to the twenty amino acids.Genomics, proteomics & bioinformatics · 2012Article
- Life on two tracks.Genomics, proteomics & bioinformatics · 2012Article
- Challenges to the common dogma.Genomics, proteomics & bioinformatics · 2012Article
- Transposon-derived and satellite-derived repetitive sequences play distinct functional roles in Mammalian intron size expansion.Evolutionary bioinformatics online · 2012Article
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2 authors.
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Abstract
backgroundWe previously have studied the insertion and deletion polymorphism by sequencing no more than one hundred introns in a mixed human population and found that the minimal introns tended to maintain length at an optimal size. Here we analyzed re-sequenced 179 individual genomes (from African, European, and Asian populations) from the data released by the 1000 Genome Project to study the size dynamics of minimal introns. PRINCIPAL
findingsWe not only confirmed that minimal introns in human populations are selected but also found two major effects in minimal intron evolution: (i) Size-effect: minimal introns longer than an optimal size (87 nt) tend to have a higher ratio of deletion to insertion than those that are shorter than the optimal size; (ii) GC-effect: minimal introns with lower GC content tend to be more frequently deleted than those with higher GC content. The GC-effect results in a higher GC content in minimal introns than their flanking exons as opposed to larger introns (≥125 nt) that always have a lower GC content than that of their flanking exons. We also observed that the two effects are distinguishable but not completely separable within and between populations.
conclusionsWe validated the unique mutation dynamics of minimal introns in keeping their near-optimal size and GC content, and our observations suggest potentially important functions of human minimal introns in transcript processing and gene regulation.
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