ArticlePloS one2011
Cooperative nuclear localization sequences lend a novel role to the N-terminal region of MSH6.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Mismatch Repair Protein Msh6International journal of molecular sciences · 2023Article
- Article
- Classification of MSH6 Variants of Uncertain Significance Using Functional Assays.International journal of molecular sciences · 2021Review
- An isolated childhood myeloid sarcoma with germline MSH6 mutation-a case report.Translational pediatrics · 2021Article
- HDAC3 deacetylates the DNA mismatch repair factor MutSβ to stimulate triplet repeat expansions.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- The Human DNA Mismatch Repair Protein MSH3 Contains Nuclear Localization and Export Signals That Enable Nuclear-Cytosolic Shuttling in Response to Inflammation.Molecular and cellular biology · 2020Article
- Toward a better definition of EPCAM deletions in Lynch Syndrome: Report of new variants in Italy and the associated molecular phenotype.Molecular genetics & genomic medicine · 2019Article
- Must Peutz-Jeghers syndrome patients have theWorld journal of clinical cases · 2018Article
- MutSFrontiers in physics · 2017Article
- Mismatch repair proteins recruit DNA methyltransferase 1 to sites of oxidative DNA damage.Journal of molecular cell biology · 2016Article
- Nuclear Localization of the DNA Repair Scaffold XRCC1: Uncovering the Functional Role of a Bipartite NLS.Scientific reports · 2015Article
- Rule-based design of synthetic transcription factors in eukaryotes.ACS synthetic biology · 2014Article
- Insights into protein - DNA interactions, stability and allosteric communications: a computational study of mutSα-DNA recognition complexes.Journal of biomolecular structure & dynamics · 2012Article
- Identification of a classical bipartite nuclear localization signal in the Drosophila TEA/ATTS protein scalloped.PloS one · 2011Article
- Structural, molecular and cellular functions of MSH2 and MSH6 during DNA mismatch repair, damage signaling and other noncanonical activities.Mutation researchReview
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Authors and funding
6 authors at 1 institution in 1 country.
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Abstract
Human mismatch repair proteins MSH2-MSH6 play an essential role in maintaining genetic stability and preventing disease. While protein functions have been extensively studied, the substantial amino-terminal region (NTR*) of MSH6 that is unique to eukaryotic proteins, has mostly evaded functional characterization. We demonstrate that a cluster of three nuclear localization signals (NLS) in the NTR direct nuclear import. Individual NLSs are capable of partially directing cytoplasmic protein into the nucleus; however only cooperative effects between all three NLSs efficiently transport MSH6 into the nucleus. In striking contrast to yeast and previous assumptions on required heterodimerization, human MSH6 does not determine localization of its heterodimeric partner, MSH2. A cancer-derived mutation localized between two of the three NLS significantly decreases nuclear localization of MSH6, suggesting altered protein localization can contribute to carcinogenesis. These results clarify the pending speculations on the functional role of the NTR in human MSH6 and identify a novel, cooperative nuclear localization signal.
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