ReviewClinical & developmental immunology2011
A spotlight on liquefaction: evidence from clinical settings and experimental models in tuberculosis.
Review in Clinical & developmental immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Aptamer-based proteomic signature of intensive phase treatment response in pulmonary tuberculosis.Tuberculosis (Edinburgh, Scotland) · 2014Trial
- Computed tomography findings in patients with pulmonary tuberculosis and diabetes at an infectious disease hospital in China: a retrospective cross-sectional study.BMC infectious diseases · 2023Article
- Association of TyG Index with CT Features in Patients with Tuberculosis and Diabetes Mellitus.Infection and drug resistance · 2022Article
- Modelling the effects of environmental heterogeneity within the lung on the tuberculosis life-cycle.Journal of theoretical biology · 2020Article
- Caseum: a Niche for Mycobacterium tuberculosis Drug-Tolerant Persisters.Clinical microbiology reviews · 2020Review
- Diverse Cavity Types and Evidence that Mechanical Action on the Necrotic Granuloma Drives Tuberculous Cavitation.The American journal of pathology · 2018Article
- Inflammatory signaling in human tuberculosis granulomas is spatially organized.Nature medicine · 2016Article
- Making sense of the cause of Crohn's - a new look at an old disease.F1000Research · 2016Review
- Oral Administration of Heat-Killed Mycobacterium manresensis Delays Progression toward Active Tuberculosis in C3HeB/FeJ Mice.Frontiers in microbiology · 2015Article
- Lesion-Specific Immune Response in Granulomas of Patients with Pulmonary Tuberculosis: A Pilot Study.PloS one · 2015Article
- The key role of exudative lesions and their encapsulation: lessons learned from the pathology of human pulmonary tuberculosis.Frontiers in microbiology · 2015Review
- The lack of a big picture in tuberculosis: the clinical point of view, the problems of experimental modeling and immunomodulation. The factors we should consider when designing novel treatment strategies.Frontiers in microbiology · 2014Review
- Article
- Article
- A multifaceted analysis of immune-endocrine-metabolic alterations in patients with pulmonary tuberculosis.PloS one · 2011Article
Corrections and comments
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Authors and funding
1 author.
Funding
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Abstract
Liquefaction is one of the most intriguing aspects of human tuberculosis. It is a major cause of the transition from the infection to active disease (tuberculosis, TB) as well as the transmission of M. tuberculosis to other persons. This paper reviews the natural history of liquefaction in humans from a pathological and radiological point of view and discusses how the experimental models available can be used to address the topic of liquefaction and cavity formation. Different concepts that have been related to liquefaction, from the influence of immune response to mechanical factors, are reviewed. Synchronic necrosis or apoptosis of infected macrophages in a close area, together with an ineffective fibrosis, appears to be clue in this process, in which macrophages, the immune response, and bacillary load interact usually in a particular scenario: the upper lobes of the lung. The summary would be that even if being a stochastic effect, liquefaction would result if the organization of the intragranulomatous necrosis (by means of fibrosis) would be disturbed.
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