ArticlePloS one2011
Brain-derived neurotrophic factor gene Val66Met polymorphism modulates reversible cerebral vasoconstriction syndromes.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Trial
- Review
- Etoricoxib and its hidden risks: a case-based review of dermatological, hematological, and cardiovascular complications.EXCLI journal · 2025Review
- Familial Reversible Cerebral Vasoconstriction Syndrome: Insights From Two Families.Case reports in neurological medicine · 2025Article
- Posterior reversible enzephalopathie syndrome (PRES) following vestibular schwannoma surgery - Case report and review of the current theories on pathophysiology of PRES.Brain & spine · 2025Review
- Reversible Cerebral Vasoconstriction Syndrome Induced by Sumatriptan: A Case Report and Review of Literature.Journal of community hospital internal medicine perspectives · 2025Article
- Treatment-Related Reversible Cerebral Vasoconstriction Syndrome.Journal of clinical medicine · 2024Review
- Pathophysiology of reversible cerebral vasoconstriction syndrome.Journal of biomedical science · 2022Review
- The Brain-Derived Neurotrophic FactorJournal of Taibah University Medical Sciences · 2019Article
- Genetic drivers of cerebral blood flow dysfunction in TBI: a speculative synthesis.Nature reviews. Neurology · 2019Review
- Brain-derived neurotrophic factor secreted by the cerebral endothelium: A new actor of brain function?Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018Review
- Intracranial Large Artery Disease of Non-Atherosclerotic Origin: Recent Progress and Clinical Implications.Journal of stroke · 2018Review
- Cerebral endothelial dysfunction in reversible cerebral vasoconstriction syndrome: a case-control study.The journal of headache and pain · 2017Article
- Reversible Cerebral Vasoconstriction Syndrome: Recognition and Treatment.Current treatment options in neurology · 2017Review
- A possible role for ghrelin, leptin, brain-derived neurotrophic factor and docosahexaenoic acid in reducing the quality of life of coeliac disease patients following a gluten-free diet.European journal of nutrition · 2017Article
- Reversible Cerebral Vasoconstriction Syndrome and Posterior Reversible Encephalopathy Syndrome Presenting with Deep Intracerebral Hemorrhage in Young Women.Journal of cerebrovascular and endovascular neurosurgery · 2015Article
- Reversible Cerebral Vasoconstriction Syndrome, Part 1: Epidemiology, Pathogenesis, and Clinical Course.AJNR. American journal of neuroradiology · 2015Review
- Reduced circulating endothelial progenitor cells in reversible cerebral vasoconstriction syndrome.The journal of headache and pain · 2014Article
- Reversible cerebral vasoconstriction syndrome (RCVS) in antiphospholipid antibody syndrome (APLA): the role of centrally acting vasodilators. Case series and review of literature.Clinical rheumatology · 2014Review
- Reversible cerebral vasoconstriction syndrome: updates and new perspectives.Current pain and headache reports · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundReversible cerebral vasoconstriction syndrome (RCVS) could be complicated by cerebral ischemic events. Hypothetical mechanisms of RCVS involve endothelial dysfunction and sympathetic overactivity, both of which were reported to be related to brain-derived neurotrophic factor (BDNF). The study investigated the association between functional BDNF Val66Met polymorphism and RCVS.
methodsPatients with RCVS and controls were prospectively recruited and genotyped for the BDNF Val66Met polymorphism. Magnetic resonance angiography (MRA) and transcranial color-coded Doppler sonography were employed to evaluate cerebral vasoconstriction. Genotyping results, clinical parameters, vasoconstriction scores, mean flow velocities of the middle cerebral artery (V(MCA)), and Lindegaard indices were analyzed. Split-sample approach was employed to internally validate the data. PRINCIPAL
findingsNinety Taiwanese patients with RCVS and 180 age- and gender-matched normal controls of the same ethnicity completed the study. The genotype frequencies did not differ between patients and controls. Compared to patients with Met/Met homozygosity, patients with Val allele had higher mean vasoconstriction scores of all arterial segments (1.60±0.72 vs. 0.87±0.39, p<0.001), V(MCA) values (116.7±36.2 vs. 82.7±17.9 cm/s, p<0.001), and LI (2.41±0.91 vs. 1.89±0.41, p = 0.001). None of the Met/Met homozygotes, but 38.9% of the Val carriers, had V(MCA) values of >120 cm/s (p<0.001). Split-sample validation by randomization, age, entry time or residence of patients demonstrated concordant findings.
conclusionsOur findings link BDNF Val66Met polymorphism with the severity of RCVS for the first time and implicate possible pathogenic mechanisms for vasoconstriction in RCVS.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.