Evidence map›Paper›PMID 21437139›Full record

ArticleJournal of asthma and allergy2008

Leukotriene receptor antagonists in monotherapy or in combination with antihistamines in the treatment of chronic urticaria: a systematic review.

Gabriele Di Lorenzo, Alberto D'Alcamo, Manfredi Rizzo, Maria Stefania Leto-Barone, Claudia Lo Bianco, Vito Ditta, Donatella Politi, Francesco Castello, Ilenia Pepe, Gaetana Di Fede and 1 more

Open access · goldAbstract read
In one paragraph

Article in Journal of asthma and allergy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 45 citations in OpenAlex.

  1. Trial
  2. Review
  3. Guideline of Chronic Urticaria Beyond.Allergy, asthma & immunology research · 2016
    Review
  4. Article
  5. Management of urticaria: not too complicated, not too simple.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2015
    Review
  6. Chronic urticaria: new management options.The World Allergy Organization journal · 2014
    Review
  7. Leukotriene receptor antagonists for chronic urticaria: a systematic review.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2014
    Review
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Gabriele Di LorenzoDipartimento di Medicina clinica e delle Patologie Emergenti;
Alberto D'Alcamo
Manfredi Rizzo
Maria Stefania Leto-Barone
Claudia Lo Bianco
Vito Ditta
Donatella Politi
Francesco Castello
Ilenia Pepe
Gaetana Di Fede
Giovambattista Rini
University of Pisa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In vitro and in vivo clinical and experimental data have suggested that leukotrienes play a key role in inflammatory reactions of the skin. Antileukotriene drugs, ie, leukotriene receptor antagonists and synthesis inhibitors, are a class of anti-inflammatory drugs that have shown clinical efficacy in the management of asthma and in rhinitis with asthma. We searched MEDLINE database and carried out a manual search on journals specializing in allergy and dermatology for the use of antileukotriene drugs in urticaria. Montelukast might be effective in chronic urticaria associated with aspirin (ASA) or food additive hypersensitivity or with autoreactivity to intradermal serum injection (ASST) when taken with an antihistamine but not in mild or moderate chronic idiopathic urticaria [urticaria without any possible secondary causes (ie, food additive or ASA and other NSAID hypersensitivity, or ASST)]. Evidence for the effectiveness of zafirlukast and the 5-lipoxygenase inhibitor, zileuton, in chronic urticaria is mainly anecdotal. In addition, there is anecdotal evidence of effectiveness of antileukotrienes in primary cold urticaria, delayed pressure urticaria and dermographism. No evidence exists for other physical urticarias, including cholinergic, solar and aquagenic urticarias, vibratory angioedema, and exercise-induced anaphylaxis.

Indexed as

antihistaminechronic idiopathic urticarialeukotriene receptor antagonistsmontelukastzafirlukast

Identifiers

PMID21437139
PMCPMC3048602
OpenAlexW2039064811

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.