ArticleGenes & nutrition2011
Human iron transporters.
Article in Genes & nutrition, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Structures and coordination chemistry of transporters involved in manganese and iron homeostasis.Biochemical Society transactions · 2023Review
- Review
- Ferroptosis is involved in regulating perioperative neurocognitive disorders: emerging perspectives.Journal of neuroinflammation · 2022Review
- Iron metabolism protein transferrin receptor 1 involves in cervical cancer progression by affecting gene expression and alternative splicing in HeLa cells.Genes & genomics · 2022Article
- The Hippo pathway kinases LATS1 and LATS2 attenuate cellular responses to heavy metals through phosphorylating MTF1.Nature cell biology · 2022Article
- Of mitochondrion and COVID-19.Journal of enzyme inhibition and medicinal chemistry · 2021Review
- Iron homeostasis in the absence of ferricrocin and its consequences in fungal development and insect virulence in Beauveria bassiana.Scientific reports · 2021Article
- Cytotrophoblast extracellular vesicles enhance decidual cell secretion of immune modulators via TNFα.Development (Cambridge, England) · 2020Article
- Intestinal DMT1 Is Essential for Optimal Assimilation of Dietary Copper in Male and Female Mice with Iron-Deficiency Anemia.The Journal of nutrition · 2018Article
- Identification of Candidate Iron Transporters From the ZIP/ZnT Gene Families in the MosquitoFrontiers in physiology · 2018Article
- Serum Hepcidin Levels, Iron Dyshomeostasis and Cognitive Loss in Alzheimer's Disease.Aging and disease · 2017Article
- Lysosomal iron modulates NMDA receptor-mediated excitation via small GTPase, Dexras1.Molecular brain · 2016Article
- Changes of ferrous iron and its transporters after intracerebral hemorrhage in rats.International journal of clinical and experimental pathology · 2015Article
- Sudden sensorineural hearing loss and polymorphisms in iron homeostasis genes: new insights from a case-control study.BioMed research international · 2015Article
- Iron-induced damage in cardiomyopathy: oxidative-dependent and independent mechanisms.Oxidative medicine and cellular longevity · 2015Review
- Paradoxical effects of heme arginate on survival of myocutaneous flaps.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Article
- Divalent metal transporter 1 (Dmt1) mediates copper transport in the duodenum of iron-deficient rats and when overexpressed in iron-deprived HEK-293 cells.The Journal of nutrition · 2013Article
- Iron increases the susceptibility of multiple myeloma cells to bortezomib.Haematologica · 2013Article
- Manganese in health and disease.Metal ions in life sciences · 2013Review
- Pharmacology of iron transport.Annual review of pharmacology and toxicology · 2013Review
Corrections and comments
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Authors and funding
1 author.
Funding
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Abstract
Human iron transporters manage iron carefully because tissues need iron for critical functions, but too much iron increases the risk of reactive oxygen species. Iron acquisition occurs in the duodenum via divalent metal transporter (DMT1) and ferroportin. Iron trafficking depends largely on the transferrin cycle. Nevertheless, non-digestive tissues have a variety of other iron transporters that may render DMT1 modestly redundant, and DMT1 levels exceed those needed for the just-mentioned tasks. This review begins to consider why and also describes advances after 2008 that begin to address this challenge.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.