ArticleEURASIP journal on bioinformatics & systems biology2011
Modeling of Neuronal Growth In Vitro: Comparison of Simulation Tools NETMORPH and CX3D.
Article in EURASIP journal on bioinformatics & systems biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- A biologically inspired repair mechanism for neuronal reconstructions with a focus on human dendrites.PLoS computational biology · 2024Article
- Tissues as networks of cells: towards generative rules of complex organ development.Journal of the Royal Society, Interface · 2023Review
- BCNNM: A Framework forFrontiers in computational neuroscience · 2020Article
- Challenges in Reproducibility, Replicability, and Comparability of Computational Models and Tools for Neuronal and Glial Networks, Cells, and Subcellular Structures.Frontiers in neuroinformatics · 2018Article
- Simulation of developing human neuronal cell networks.Biomedical engineering online · 2016Article
- Simulating cortical development as a self constructing process: a novel multi-scale approach combining molecular and physical aspects.PLoS computational biology · 2013Article
- Structure-dynamics relationships in bursting neuronal networks revealed using a prediction framework.PloS one · 2013Article
- Information diversity in structure and dynamics of simulated neuronal networks.Frontiers in computational neuroscience · 2011Article
Corrections and comments
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Authors and funding
5 authors.
Funding
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Abstract
We simulate the growth of neuronal networks using the two recently published tools, NETMORPH and CX3D. The goals of the work are (1) to examine and compare the simulation tools, (2) to construct a model of growth of neocortical cultures, and (3) to characterize the changes in network connectivity during growth, using standard graph theoretic methods. Parameters for the neocortical culture are chosen after consulting both the experimental and the computational work presented in the literature. The first (three) weeks in culture are known to be a time of development of extensive dendritic and axonal arbors and establishment of synaptic connections between the neurons. We simulate the growth of networks from day 1 to day 21. It is shown that for the properly selected parameters, the simulators can reproduce the experimentally obtained connectivity. The selected graph theoretic methods can capture the structural changes during growth.
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Registered trials
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