ArticleEplasty2011
Telomere dynamics in keloids.
Article in Eplasty, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The role of IL-17 and Th17 cells in keloid pathogenesis.Archives of dermatological research · 2024Pooled it
- Leukocyte Telomeric G-Tail Length Shortening Is Associated with Esophageal Cancer Recurrence.Journal of clinical medicine · 2022Article
- The Keloid Disorder: Heterogeneity, Histopathology, Mechanisms and Models.Frontiers in cell and developmental biology · 2020Review
- From organ to cell: Multi-level telomere length assessment in patients with idiopathic pulmonary fibrosis.PloS one · 2020Article
- Understanding Keloid Pathobiology From a Quasi-Neoplastic Perspective: Less of a Scar and More of a Chronic Inflammatory Disease With Cancer-Like Tendencies.Frontiers in immunology · 2019Review
- Association between leukocyte telomere length and the risk of pancreatic cancer: Findings from a prospective study.PloS one · 2019Article
- Leukocyte telomere length in relation to risk of lung adenocarcinoma incidence: Findings from the Singapore Chinese Health Study.International journal of cancer · 2018Article
- Cumulative PM(2.5) exposure and telomere length in workers exposed to welding fumes.Journal of toxicology and environmental health. Part A · 2014Article
- Article
- Telomeres shorten at equivalent rates in somatic tissues of adults.Nature communications · 2013Article
- Divergence of sperm and leukocyte age-dependent telomere dynamics: implications for male-driven evolution of telomere length in humans.Molecular human reproduction · 2012Article
- Genetics of leukocyte telomere length and its role in atherosclerosis.Mutation research · 2012Review
- The keloid strikes back.Eplasty · 2012Article
- A model of canine leukocyte telomere dynamics.Aging cell · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveLittle is known about telomere dynamics in keloids. As keloid formation is dependent on cell replication, in theory telomeres should be shorter in keloids than in normal skin. We examined this concept in the present study.
methodsWe measured by Southern blot analysis telomere length in keloids and in adjacent normal skin of 16 individuals. When available, we also measured telomere length in blood (leukocytes) and subcutaneous fat.
resultsTelomere length was highly variable among individuals but highly correlated among tissues (cells) within the individual. The mean telomere length in the keloids was longer than that in the adjacent normal skin and displayed a length gradient, with the mean length of telomeres shorter just below the epidermis and longer at the base of the keloids. No apparent telomerase activity was detected in the keloids.
conclusionsOur findings suggest a transient activation of telomerase, the reverse transcriptase that prevents telomere shortening, probably during the early phase of keloid formation. The activation of telomerase serves to maintain (or even elongate) telomere length in the keloid. However, telomerase activity is repressed in the fully developed keloid.
Identifiers
21436892PMC3060056What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.