ArticleEvidence-based dentistry2011
Industry sponsored research may report more favourable outcomes.
Article in Evidence-based dentistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.
- Industry sponsorship and research outcome.The Cochrane database of systematic reviews · 2017Pooled it
- Commentary on two reviews of anterior composite restorations.Evidence-based dentistry · 2016Article
- Standardizing failure, success, and survival decisions in clinical studies of ceramic and metal-ceramic fixed dental prostheses.Dental materials : official publication of the Academy of Dental Materials · 2012Review
Corrections and comments
- Comment on
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
data sourcesMedline and the Cochrane Database of systematic reviews between January 1993 and December 2008. Hand search of 12 different dental journals (Journal of Periodontology, International Dental Journal, British Dental Journal, Journal of the International Academy of Periodontology, Journal Canadian Dental Association, Swedish Dental Journal, Quintessence International, Journal of Clinical Periodontology, Periodontology 2000, Clinical Oral Implant Research, International Journal of Oral and Maxillofacial Implants, International Journal of Prosthodontic, Journal of Prosthetic Dentistry). Language restricted to English. STUDY SELECTION: Primary articles from systematic reviews that specifically studied the length of survival of dental implants. DATA EXTRACTION AND SYNTHESIS: Primary studies were extracted from reviews for which the following information was available: the failure rate of dental implants, publication year, journal Impact Factor, prosthetic design periodontal status, number of dental implants included in the study, methodological quality of studies, presence of a statistical advisor and financial sponsorship. Univariant quasi-Poisson regression and multivariate analysis were used to identity variables that were significantly associated with failure rates.
resultsTwo independent reviewers identified five systematic reviews from which 41 analysable trials were extracted (Kappa 0.90; 95%CI 0.77 - 1.00). The mean annual failure rate estimate for all trials was 1.09% (95%CI 0.84 - 1.42). The mean annual failure rate estimate of non-industry funded trials was 2.74% (95%CI 1.14 - 6.55). Four trials (10%) reported non-industry funding sources. The funding source was not reported in 26 trials (63%). 27 trials (66%) were considered to have a risk of bias. Given study age, both industry associated (OR= 0.21; 95%CI 0.12 - 0.38) and unknown funding sources trials (OR = 0.33; 95%CI 0.21 - 0.51) had a lower annual failure rate compared with non-industry associated trials. A conflict of interest statement was provided in 2 trials (5%).
conclusionsAfter controlling for other factors, the probability of annual implant failure reported in industry associated trials is significantly lower compared with non-industry associated trials. This bias may have significant impact on tooth extraction decision making, research on tooth preservation and government health care policies.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.