ReviewNature reviews. Immunology2011
Platelets and the immune continuum.
Review in Nature reviews. Immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06715215 (Role of Acute Phase Proteins In Diagnosis of Immune Thrombocytopenia), which is not on this map. Cited by 809 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Role of Acute Phase Proteins In Diagnosis of Immune Thrombocytopenia
Who cites it
809 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The predictive value of immune inflammation indexes for the risk of fracture in patients with osteoporosis: a systematic review and meta-analysis.Frontiers in endocrinology · 2025Pooled it
- Efficacy of Platelet-Rich Plasma Therapy in Oral Lichen Planus: A Systematic Review.Medicina (Kaunas, Lithuania) · 2023Pooled it
- Platelet-derived serotonin epigenetically programs macrophage alternative activation to orchestrate type 2 airway inflammation.Cellular & molecular immunology · 2026Article
- From haemostasis to immunity: The expanding frontiers of platelet biology.British journal of haematology · 2026Review
- Isaridin E Attenuates Ischemic Brain Injury in Mice by Concurrently Reducing Platelet Hyperactivity and Microglial Neuroinflammation Associated with LRP1.Marine drugs · 2026Article
- Beyond Lesions: Systemic Inflammatory and Metabolic Characterization of Swine Inflammation and Necrosis Syndrome.Animals : an open access journal from MDPI · 2026Article
- NLRP3 inflammasome partially mediates genotoxiciScience · 2026Article
- Elevated Preoperative Systemic Immune-Inflammation Index Independently Predicts 30-Day Mortality After Living Donor Liver Transplantation.Life (Basel, Switzerland) · 2026Article
- Platelets as regulators of anti-tumor immunity: mechanisms and clinical implications.Cancer metastasis reviews · 2026Review
- Article
- Observational
- The Relationship Between Severity of Apical Periodontitis and Next-Generation Systemic Inflammatory Biomarkers.Australian endodontic journal : the journal of the Australian Society of Endodontology Inc · 2026Article
- FVIII-containing platelets modulate immune responses and attenuate inhibitor development in hemophilia A mice.Haematologica · 2026Article
- Preoperative platelet-related inflammatory burden is associated with delayed early hemodynamic recovery following minimally invasive cardiac surgery.BMC cardiovascular disorders · 2026Observational
- The LAV-BPIFB4-Platelet-CD47 Axis: A Novel Mechanism Associated With Immune Resilience in Longevity.Aging cell · 2026Article
- Biomimetic Cell Membrane-Based Drug Delivery Systems for Oral Diseases: Engineering Strategies, Targeting Mechanisms, and Translational Challenges.Pharmaceutics · 2026Review
- Sharp-Wave EEG Activity and Cytomegalovirus Exposure in Schizophrenia Spectrum Disorders: A Neuroimmune Perspective.Journal of clinical medicine · 2026Article
- Time for a More Precise and Practical Laboratory Definition of Metainflammation in Obesity-Related Diseases.Medical sciences (Basel, Switzerland) · 2026Article
- Neutrophil-to-Lymphocyte Ratio, Systemic Immune-Inflammation Index, and HALP Score as Predictors of Mortality in Acute Respiratory Distress Syndrome.Journal of clinical medicine · 2026Article
- Strategies for in-depth and simultaneous analysis of N- and O-glycoproteome of platelets uncovering sex-specific signatures of human platelets.Analytical and bioanalytical chemistry · 2026Article
749 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Platelets are anucleate cells that are crucial mediators of haemostasis. Most immunologists probably don't think about platelets every day, and may even consider these cells to be 'nuisances' in certain in vitro studies. However, it is becoming increasingly clear that platelets have inflammatory functions and can influence both innate and adaptive immune responses. Here, we discuss the mechanisms by which platelets contribute to immunity: these small cells are more immunologically savvy than we once thought.
Indexed as
Identifiers
21436837What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.