Evidence map›Paper›PMID 21436714›Full record

ArticleJournal of acquired immune deficiency syndromes (1999)2011

Time to initiation of antiretroviral therapy among patients with HIV-associated tuberculosis in Cape Town, South Africa.

Stephen D Lawn, Lucy Campbell, Richard Kaplan, Andrew Boulle, Morna Cornell, Bernhard Kerschberger, Carl Morrow, Francesca Little, Matthias Egger, Robin Wood and 1 more

Abstract read
In one paragraph

Article in Journal of acquired immune deficiency syndromes (1999), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Trial
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Delayed antiretroviral therapy despite integrated treatment for tuberculosis and HIV infection.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2014
    Observational
  14. Article
  15. Article
  16. Outcomes in HIV-infected adults with tuberculosis at clinics with and without co-located HIV clinics in Botswana.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2013
    Article
  17. Article
  18. Review
  19. Antiretroviral treatment uptake in patients with HIV-associated TB attending co-located TB and ART services.South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde · 2012
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Stephen D LawnThe Desmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa. stevelawn@yahoo.co.uk
Lucy Campbell
Richard Kaplan
Andrew Boulle
Morna Cornell
Bernhard Kerschberger
Carl Morrow
Francesca Little
Matthias Egger
Robin Wood
International Epidemiological Databases to Evaluate AIDS-Southern Africa

Funding

Observational Antiretroviral Studies In Southern Africa (OASIS) CollaborationU01AI069924 · NIAID · UNIVERSITAT BERN · PI Cleophas Chimbetete, Mary-Ann Davies · 2006 to 2026
$55.9M
The effect of ART on rates and transmission of TBU19AI053217 · NIAID · WITS HEALTH CONSORTIUM (PTY), LTD · PI MCINTYRE, JAMES ALASDAIR · 2002 to 2011
$44.9M
NIAID NIH HHS 1U19AI53217-01NIAID NIH HHS 5 U01 AI069924-02NIAID NIH HHS 5U01AI069924-05NIAID NIH HHS U01 AI069924NIAID NIH HHS U19 AI053217PHS HHS A1058736-01A1Wellcome Trust 088590
6 · The paper itself

Abstract

We studied the time interval between starting tuberculosis treatment and commencing antiretroviral treatment (ART) in HIV-infected patients (n = 1433; median CD4 count 71 cells per microliter, interquartile range: 32-132) attending 3 South African township ART services between 2002 and 2008. The overall median delay was 2.66 months (interquartile range: 1.58-4.17). In adjusted analyses, delays varied between treatment sites but were shorter for patients with lower CD4 counts and those treated in more recent calendar years. During the most recent period (2007-2008), 4.7%, 19.7%, and 51.1% of patients started ART within 2, 4, and 8 weeks of tuberculosis treatment, respectively. Operational barriers must be tackled to permit further acceleration of ART initiation as recommended by 2010 WHO ART guidelines.

Indexed as

AdolescentAdultAIDS-Related Opportunistic InfectionsAnti-HIV AgentsAntitubercular AgentsCD4 Lymphocyte CountCohort StudiesFemaleHIV InfectionsHumansMaleMiddle AgedSouth AfricaTime FactorsTuberculosisYoung AdultAnti-HIV AgentsAntitubercular Agents

Identifiers

PMID21436714
PMCPMC3717455

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.