Evidence map›Paper›PMID 21436580›Full record

ArticleThe Journal of clinical investigation2011

PinX1 the tail on the chromosome.

F Brad Johnson

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical investigation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Association of theJournal of immunology research · 2021
    Observational
  4. Article
  5. Article
  6. Telomere length as a potential biomarker of coronary artery disease.The Indian journal of medical research · 2017
    Review
  7. Article
  8. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

F Brad JohnsonDepartment of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA. johnsonb@mail.med.upenn.edu
University of Pennsylvania · US

Funding

Telomere maintenance by Werner syndrome family proteins.R01AG021521 · NIA · UNIVERSITY OF PENNSYLVANIA · PI JOHNSON, F. BRAD · 2004 to 2013
$2.8M
Telomere maintenance by Werner syndrome family proteinsR55AG021521 · NIA · UNIVERSITY OF PENNSYLVANIA · PI JOHNSON, FREDERICK BRADLEY · 2003 to 2003
$100k
NIA NIH HHS AG021521NIA NIH HHS R01 AG021521NIA NIH HHS R55 AG021521
6 · The paper itself

Abstract

The PinX1 protein inhibits telomerase, an enzyme that lengthens telomeres - the structures that protect the ends of chromosomes. Loss of PinX1 leads to increased telomere length along with defects in chromosome dynamics. In this issue of the JCI, Zhou et al. present novel evidence from human tumors and mouse models indicating that PinX1 is a clinically significant tumor suppressor. Importantly, the genome-destabilizing effects of PinX1 loss appear to depend on telomerase activity, raising new models and questions for how telomeres and telomerase contribute to the development of cancer.

Indexed as

AnimalsCell Cycle ProteinsCell Line, TumorChromosomal InstabilityFemaleHaploinsufficiencyHumansMiceNeoplasmsNuclear ProteinsTelomeraseTumor Suppressor ProteinsCell Cycle ProteinsNuclear ProteinsPINX1 protein, humanPinx1 protein, mouseTelomeraseTumor Suppressor Proteins

Identifiers

PMID21436580
PMCPMC3069792
OpenAlexW2156741630

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.