ArticleBiomedical materials (Bristol, England)2011
Tendon tissue engineering: adipose-derived stem cell and GDF-5 mediated regeneration using electrospun matrix systems.
Article in Biomedical materials (Bristol, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.
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Who cites it
61 citing papers in PubMed, 1 synthesis or guideline pooled it, 161 citations in OpenAlex.
- Nanofiber Technology for Regenerative Engineering.ACS nano · 2020Pooled it
- Nano-layered tendon patch to orchestrate timely interactions between tendon stem/progenitor cells and macrophages.Biomaterials · 2027Article
- Grafts in tendon repair.Materials today. Bio · 2026Review
- FIBER DIAMETER-DRIVEN MODULATION OF CELL BEHAVIOR IN DECM-ENRICHED ELECTROSPUN SCAFFOLDS FOR BONE TISSUE ENGINEERING.International journal of high speed electronics · 2026Article
- ColMA-based bioprinted 3D scaffold allowed to study tenogenic events in human tendon stem cells.Bioengineering & translational medicine · 2025Article
- Electrospinning technology: a promising approach for tendon-bone interface tissue engineering.RSC advances · 2024Review
- Nanofiber matrix formulations for the delivery of Exendin-4 for tendon regeneration:Bioactive materials · 2023Article
- Natural, synthetic and commercially-available biopolymers used to regenerate tendons and ligaments.Bioactive materials · 2023Review
- Biological approaches to the repair and regeneration of the rotator cuff tendon-bone enthesis: a literature review.Biomaterials translational · 2023Review
- Electrospinning of Biomedical Nanofibers/Nanomembranes: Effects of Process Parameters.Polymers · 2022Review
- Adipose-derived mesenchymal stem cells with hypoxic preconditioning improve tenogenic differentiation.Journal of orthopaedic surgery and research · 2022Article
- Impact of Electrospun Piezoelectric Core-Shell PVDFhfp/PDMS Mesh on Tenogenic and Inflammatory Gene Expression in Human Adipose-Derived Stem Cells: Comparison of Static Cultivation with Uniaxial Cyclic Tensile Stretching.Bioengineering (Basel, Switzerland) · 2022Article
- Review
- Green electrospinning for biomaterials and biofabrication.Biofabrication · 2021Article
- Fibrous Systems as Potential Solutions for Tendon and Ligament Repair, Healing, and Regeneration.Advanced healthcare materials · 2021Review
- The Lack of a Representative Tendinopathy Model Hampers Fundamental Mesenchymal Stem Cell Research.Frontiers in cell and developmental biology · 2021Review
- Biodegradable reduction and pH dual-sensitive polymer micelles based on poly(2-ethyl-2-oxazoline) for efficient delivery of curcumin.RSC advances · 2020Article
- Article
- Development of Tripolymeric Triaxial Electrospun Fibrous Matrices for Dual Drug Delivery Applications.Scientific reports · 2020Article
- Supporting Cell-Based Tendon Therapy: Effect of PDGF-BB and Ascorbic Acid on Rabbit Achilles Tenocytes in Vitro.International journal of molecular sciences · 2020Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Tendon tissue engineering with a biomaterial scaffold that mimics the tendon extracellular matrix (ECM) and is biomechanically suitable, and when combined with readily available autologous cells, may provide successful regeneration of defects in tendon. Current repair strategies using suitable autografts and freeze-dried allografts lead to a slow repair process that is sub-optimal and fails to restore function, particularly in difficult clinical situations such as zone II flexor tendon injuries of the hand. We have investigated the effect of GDF-5 on cell proliferation and gene expression by primary rat adipose-derived stem cells (ADSCs) that were cultured on a poly(DL-lactide-co-glycolide) PLAGA fiber scaffold and compared to a PLAGA 2D film scaffold. The electrospun scaffold mimics the collagen fiber bundles present in native tendon tissue, and supports the adhesion and proliferation of multipotent ADSCs. Gene expression of scleraxis, the neotendon marker, was upregulated seven- to eightfold at 1 week with GDF-5 treatment when cultured on a 3D electrospun scaffold, and was significantly higher at 2 weeks compared to 2D films with or without GDF-5 treatment. Expression of the genes that encode the major tendon ECM protein, collagen type I, was increased by fourfold starting at 1 week on treatment with 100 ng mL(-1) GDF-5, and at all time points the expression was significantly higher compared to 2D films irrespective of GDF-5 treatment. Thus stimulation with GDF-5 can modulate primary ADSCs on a PLAGA fiber scaffold to produce a soft, collagenous musculoskeletal tissue that fulfills the need for tendon regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.