ArticleJournal of applied physiology (Bethesda, Md. : 1985)2011
Reactive oxygen species (ROS) from NADPH and xanthine oxidase modulate the cutaneous local heating response in healthy humans.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 62 citations in OpenAlex.
- Apocynin and Tempol ameliorate dietary sodium-induced declines in cutaneous microvascular function in salt-resistant humans.American journal of physiology. Heart and circulatory physiology · 2019Trial
- Peripheral Microvascular Vasodilatory Response to Estradiol and Genistein in Women with Insulin Resistance.Microcirculation (New York, N.Y. : 1994) · 2015Trial
- Oral atorvastatin therapy increases nitric oxide-dependent cutaneous vasodilation in humans by decreasing ascorbate-sensitive oxidants.American journal of physiology. Regulatory, integrative and comparative physiology · 2011Trial
- Creatine monohydrate supplementation and NOX impact skeletal muscle microvascular blood flow: a pilot study.Pflugers Archiv : European journal of physiology · 2025Article
- The Cellular and Organismal Effects of Nitroxides and Nitroxide-Containing Nanoparticles.International journal of molecular sciences · 2024Review
- Endothelin A receptor inhibition increases nitric oxide-dependent vasodilation independent of superoxide in non-Hispanic Black young adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Photoactivatable nanogenerators of reactive species for cancer therapy.Bioactive materials · 2021Review
- The Dietary Fructose:Vitamin C Intake Ratio Is Associated with Hyperuricemia in African-American Adults.The Journal of nutrition · 2018Article
- Fluid replacement modulates oxidative stress- but not nitric oxide-mediated cutaneous vasodilation and sweating during prolonged exercise in the heat.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- No effect of ascorbate on cutaneous vasodilation and sweating in older men and those with type 2 diabetes exercising in the heat.Physiological reports · 2017Article
- Microvascular Endothelial Dysfunction in Sedentary, Obese Humans Is Mediated by NADPH Oxidase: Influence of Exercise Training.Arteriosclerosis, thrombosis, and vascular biology · 2016Article
- A microdialysis method to measure in vivo hydrogen peroxide and superoxide in various rodent tissues.Methods (San Diego, Calif.) · 2016Article
- Regulation of exercise blood flow: Role of free radicals.Free radical biology & medicine · 2016Review
- Passive heat therapy improves cutaneous microvascular function in sedentary humans via improved nitric oxide-dependent dilation.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Evidence of microvascular dysfunction in patients with cystic fibrosis.American journal of physiology. Heart and circulatory physiology · 2016Article
- Can intradermal administration of angiotensin II influence human heat loss responses during whole body heat stress?Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- Nitroxide pharmaceutical development for age-related degeneration and disease.Frontiers in genetics · 2015Review
- New approach to measure cutaneous microvascular function: an improved test of NO-mediated vasodilation by thermal hyperemia.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- NADPH oxidase-derived reactive oxygen species contribute to impaired cutaneous microvascular function in chronic kidney disease.American journal of physiology. Renal physiology · 2014Article
- Tempol improves cutaneous thermal hyperemia through increasing nitric oxide bioavailability in young smokers.American journal of physiology. Heart and circulatory physiology · 2014Article
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5 authors at 1 institution in 1 country.
Funding
Abstract
Local cutaneous heating produces vasodilation that is largely nitric oxide (NO) dependent. We showed that angiotensin II (ANG II) attenuates this by an ANG II receptor, type 1 (AT1R)-dependent mechanism that is reversible with the antioxidant ascorbate, indicating oxidative stress. Reactive oxygen species (ROS) produced by ANG II employ NADPH and xanthine oxidase pathways. To determine whether these mechanisms pertain to skin, we measured cutaneous local heating with 10 μM ANG II, using apocynin to inhibit NADPH oxidase and allopurinol to inhibit xanthine oxidase. We also inhibited superoxide with tempol, and H(2)O(2) with ebselen. We heated the skin of the calf in 8 healthy volunteers (24.5-29.9 yr old) to 42°C and measured local blood flow to assess the percentage of maximum cutaneous vascular conductance. We remeasured while perfusing allopurinol, apocynin, ebselen, and tempol through individual microdialysis catheters. This was then repeated with ANG II combined with antioxidant drugs. tempol and apocynin alone had no effect on the heat response. Allopurinol enhanced the entire response (125% of heat alone), while ebselen suppressed the heat plateau (76% of heat alone). ANG II alone caused significant attenuation of the entire heat response (52%). When added to ANG II, Allopurinol partially reversed the ANG II attenuation. Heat with ebselen and ANG II were similar to heat and ANG II; ebselen only partially reversed the ANG II attenuation. Apocynin and tempol each partially reversed the attenuation caused by ANG II. This suggests that ROS, produced by ANG II via NADPH and xanthine oxidase pathways, modulates the response of skin to the application of heat, and thus contributes to the control of local cutaneous blood flow.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.