ArticleLearning & memory (Cold Spring Harbor, N.Y.)2011
Impact of infralimbic inputs on intercalated amygdala neurons: a biophysical modeling study.
Article in Learning & memory (Cold Spring Harbor, N.Y.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 40 citations in OpenAlex.
- Amygdala Intercalated Cells: Gate Keepers and Conveyors of Internal State to the Circuits of Emotion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Review
- Aberrant orbitofrontal cortical activation interferes with encoding of Pavlovian fear conditioning.Frontiers in behavioral neuroscience · 2022Article
- Multiscale neural modeling of resting-state fMRI reveals executive-limbic malfunction as a core mechanism in major depressive disorder.NeuroImage. Clinical · 2021Article
- Interplay of prefrontal cortex and amygdala during extinction of drug seeking.Brain structure & function · 2018Article
- Dynamic expression of FKBP5 in the medial prefrontal cortex regulates resiliency to conditioned fear.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- Neurodevelopmental Hypothesis about the Etiology of Autism Spectrum Disorders.Frontiers in human neuroscience · 2017Article
- Article
- Uncertainty-Dependent Extinction of Fear Memory in an Amygdala-mPFC Neural Circuit Model.PLoS computational biology · 2016Article
- The intercalated nuclear complex of the primate amygdala.Neuroscience · 2016Article
- Biologically based neural circuit modelling for the study of fear learning and extinction.NPJ science of learning · 2016Article
- The Role of the Medial Prefrontal Cortex in the Conditioning and Extinction of Fear.Frontiers in behavioral neuroscience · 2015Review
- Mechanisms to medicines: elucidating neural and molecular substrates of fear extinction to identify novel treatments for anxiety disorders.British journal of pharmacology · 2014Review
- The amygdala: securing pleasure and avoiding pain.Frontiers in behavioral neuroscience · 2013Review
- Fear signaling in the prelimbic-amygdala circuit: a computational modeling and recording study.Journal of neurophysiology · 2013Article
- Exposure to a fearful context during periods of memory plasticity impairs extinction via hyperactivation of frontal-amygdalar circuits.Learning & memory (Cold Spring Harbor, N.Y.) · 2013Article
- A model of amygdala-hippocampal-prefrontal interaction in fear conditioning and extinction in animals.Brain and cognition · 2013Article
- Anatomy and computational modeling of networks underlying cognitive-emotional interaction.Frontiers in human neuroscience · 2013Article
- Increased hippocampal volume and gene expression following cognitive behavioral therapy in PTSD.Frontiers in human neuroscience · 2013Article
- Amygdala microcircuits mediating fear expression and extinction.Current opinion in neurobiology · 2012Review
- Medial prefrontal cortical innervation of the intercalated nuclear region of the amygdala.Neuroscience · 2012Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Intercalated (ITC) amygdala neurons regulate fear expression by controlling impulse traffic between the input (basolateral amygdala; BLA) and output (central nucleus; Ce) stations of the amygdala for conditioned fear responses. Previously, stimulation of the infralimbic (IL) cortex was found to reduce fear expression and the responsiveness of Ce neurons to BLA inputs. These effects were hypothesized to result from the activation of ITC cells projecting to Ce. However, ITC cells inhibit each other, leading to the question of how IL inputs could overcome the inter-ITC inhibition to regulate the responses of Ce neurons to aversive conditioned stimuli (CSs). To investigate this, we first developed a compartmental model of a single ITC cell that could reproduce their bistable electroresponsive properties, as observed experimentally. Next, we generated an ITC network that implemented the experimentally observed short-term synaptic plasticity of inhibitory inter-ITC connections. Model experiments showed that strongly adaptive CS-related BLA inputs elicited persistent responses in ITC cells despite the presence of inhibitory interconnections. The sustained CS-evoked activity of ITC cells resulted from an unusual slowly deinactivating K(+) current. Finally, over a wide range of stimulation strengths, brief IL activation caused a marked increase in the firing rate of ITC neurons, leading to a persistent decrease in Ce output, despite inter-ITC inhibition. Simulations revealed that this effect depended on the bistable properties and synaptic heterogeneity of ITC neurons. These results support the notion that IL inputs are in a strategic position to control extinction of conditioned fear via the activation of ITC neurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.