ArticleAJNR. American journal of neuroradiology2011
Magnetization transfer imaging demonstrates a distributed pattern of microstructural changes of the cerebral cortex in amyotrophic lateral sclerosis.
Article in AJNR. American journal of neuroradiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Biomarkers in Motor Neuron Disease: A State of the Art Review.Frontiers in neurology · 2019Review
- MR Imaging-based Estimation of Upper Motor Neuron Density in Patients with Amyotrophic Lateral Sclerosis: A Feasibility Study.Radiology · 2018Article
- Emerging Magnetic Resonance Imaging Techniques and Analysis Methods in Amyotrophic Lateral Sclerosis.Frontiers in neurology · 2018Review
- Article
- Immediate and Longitudinal Alterations of Functional Networks after Thalamotomy in Essential Tremor.Frontiers in neurology · 2016Article
- Parameters of glucose metabolism and the aging brain: a magnetization transfer imaging study of brain macro- and micro-structure in older adults without diabetes.Age (Dordrecht, Netherlands) · 2015Article
- Lower Blood Pressure and Gray Matter Integrity Loss in Older Persons.Journal of clinical hypertension (Greenwich, Conn.) · 2015Article
- Structural and functional hallmarks of amyotrophic lateral sclerosis progression in motor- and memory-related brain regions.NeuroImage. Clinical · 2014Article
- Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis.Nature neuroscience · 2013Article
- Mapping cortical degeneration in ALS with magnetization transfer ratio and voxel-based morphometry.PloS one · 2013Article
- A distinct MR imaging phenotype in amyotrophic lateral sclerosis: correlation between T1 magnetization transfer contrast hyperintensity along the corticospinal tract and diffusion tensor imaging analysis.AJNR. American journal of neuroradiology · 2012Article
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10 authors.
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Abstract
background and purposeTo date, damage of the cerebral cortex neurons in ALS was investigated by using conventional MR imaging and proton MR spectroscopy. We explored the capability of MTI to map the microstructural changes in cerebral motor and extramotor cortices of patients with ALS. MATERIALS AND
methodsTwenty patients with ALS and 17 age-matched healthy controls were enrolled. A high-resolution 3D SPGR sequence with and without MT saturation pulses was obtained on a 1.5T scanner to compute MTR values. Using the FMRIB Software Library tools, we automatically computed the MTR of the cerebral cortex GM in 48 regions of the entire cerebral cortex derived from the standard Harvard-Oxford cortical atlas.
resultsThe MTR values were significantly lower in patients with ALS than in healthy controls in the primary motor cortex (precentral gyrus), nonprimary motor areas (superior and middle frontal gyri and superior parietal lobe), and some extramotor areas (frontal pole, planum temporale, and planum polare). No correlation was found between regional MTR values and the severity of clinical deficits or disease duration.
conclusionsMTI analysis can detect the distributed pattern of microstructural changes of the GM in the cerebral cortex of patients with ALS with involvement of both the motor and extramotor areas.
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