ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2011
Small intestine CD11c+ CD8+ T cells suppress CD4+ T cell-induced immune colitis.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
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- TIPE2 Promotes Tumor Initiation But Inhibits Tumor Progression in Murine Colitis-Associated Colon Cancer.Inflammatory bowel diseases · 2022Article
- Mitigation of DSS-Induced Colitis Potentially via Th1/Th2 Cytokine and Immunological Function Balance Induced by Phenolic-Enriched Buckwheat (Foods (Basel, Switzerland) · 2022Article
- Phenotypic and functional alteration of CD45+ immune cells in the decidua of preeclampsia patients analyzed by mass cytometry (CyTOF).Frontiers in immunology · 2022Article
- The autoimmune susceptibility gene,Gut microbes · 2020Article
- Impact of TGEV infection on the pig small intestine.Virology journal · 2018Article
- Therapeutic effect of curcumin on experimental colitis mediated by inhibiting CD8World journal of gastroenterology · 2017Article
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- Tumoricidal efficacy coincides with CD11c up-regulation in antigen-specific CD8(+) T cells during vaccine immunotherapy.Journal of experimental & clinical cancer research : CR · 2016Article
- Article
- Expression of CD11c Is Associated with Unconventional Activated T Cell Subsets with High Migratory Potential.PloS one · 2016Article
- T Lymphocyte Dynamics in Inflammatory Bowel Diseases: Role of the Microbiome.BioMed research international · 2015Review
- Altered generation of induced regulatory T cells in the FVB.mdr1a-/- mouse model of colitis.Mucosal immunology · 2013Article
- Transforming growth factor β signaling controls activities of human intestinal CD8(+)T suppressor cells.Gastroenterology · 2013Article
- Working out mechanisms of controlled/physiologic inflammation in the GI tract.Immunologic research · 2012Review
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The large (LI) and small intestine (SI) differ in patterns of susceptibility to chronic mucosal inflammation. In this study, we evaluated whether this might, in part, reflect differences in resident mucosal CD11c(+) T cells. These cells comprised 39-48% (SI) and 12-17% (LI) of the intraepithelial compartment, most of which were T-cell receptor-αβ(+). In the SI, the majority of these cells were CD103(+) CD8(+) NK1.1(-), whereas the opposite phenotype prevailed in the LI. In transfer models of CD4(+) T cell-induced colitis, small numbers (2.5 × 10(5)) of SI CD11c(+) CD8(+) T cells suppressed proinflammatory cytokine-producing CD4(+) T cells in mesenteric lymph nodes and mucosa-associated lymphoid compartments (SI and LI) and protected mice from chronic inflammation. On a per-cell basis, the regulatory function of SI CD11c(+) T cells in CD4(+) T cell colitis was potent compared with other reported regulatory CD4(+) or CD8(+) T cells. In contrast, neither LI CD11c(+) T cells nor SI CD11c(-) T cells were effective in such immunoregulation. SI CD11c(+) CD8(+) T cells were similarly effective in suppressing CD4(+)CD45RB(hi) T cell colitis, as evidenced by inhibition of intracellular proinflammatory cytokine expression and histological inflammation. These findings indicate that SI CD11c(+) CD8(+) T cells are a distinct intestinal T cell population that plays an immunoregulatory role in control of proinflammatory CD4(+) T cells and maintenance of intestinal mucosal homeostasis.
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Registered trials
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