ArticleJournal of the American Society of Nephrology : JASN2011
β-catenin causes renal dysplasia via upregulation of Tgfβ2 and Dkk1.
Article in Journal of the American Society of Nephrology : JASN, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 42 citations in OpenAlex.
- Loss of minichromosome maintenance 4 leads to early renal dysplasia and cystogenesis outcomes.Genes & diseases · 2026Article
- Epithelial cell shape changes contribute to regulation of ureteric bud branching morphogenesis.The FEBS journal · 2025Article
- Wnt/β-Catenin Signaling and Congenital Abnormalities of Kidney and Urinary Tract.Kidney diseases (Basel, Switzerland) · 2024Review
- Deciphering the cellular and molecular landscapes of Wnt/β-catenin signaling in mouse embryonic kidney development.Computational and structural biotechnology journal · 2024Article
- CRISPR-SID: Identifying EZH2 as a druggable target for desmoid tumors via in vivo dependency mapping.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Calreticulin Deficiency Disturbs Ribosome Biogenesis and Results in Retardation in Embryonic Kidney Development.International journal of molecular sciences · 2021Article
- Impact of gestational low-protein intake on embryonic kidney microRNA expression and in nephron progenitor cells of the male fetus.PloS one · 2021Article
- Quercetin treatment reduces the severity of renal dysplasia in a beta-catenin dependent manner.PloS one · 2020Article
- Review
- Regulation of Renal Differentiation by Trophic Factors.Frontiers in physiology · 2018Review
- Blocking TGF-Journal of the American Society of Nephrology : JASN · 2017Article
- Developmental Origins for Kidney Disease Due to Shroom3 Deficiency.Journal of the American Society of Nephrology : JASN · 2016Article
- Integrin-linked Kinase Controls Renal Branching Morphogenesis via Dual Specificity Phosphatase 8.Journal of the American Society of Nephrology : JASN · 2016Article
- LDL Receptor-Related Protein 6 Modulates Ret Proto-Oncogene Signaling in Renal Development and Cystic Dysplasia.Journal of the American Society of Nephrology : JASN · 2016Article
- Histone deacetylase 1 and 2 regulate Wnt and p53 pathways in the ureteric bud epithelium.Development (Cambridge, England) · 2015Article
- The ureteric bud epithelium: morphogenesis and roles in metanephric kidney patterning.Molecular reproduction and development · 2015Review
- The Good and Bad of β-Catenin in Kidney Development and Renal Dysplasia.Frontiers in cell and developmental biology · 2015Review
- A Wnt-TGFβ2 axis induces a fibrogenic program in muscle stem cells from dystrophic mice.Science translational medicine · 2014Article
- Patterning the renal vascular bed.Seminars in cell & developmental biology · 2014Review
- CITED1 confers stemness to Wilms tumor and enhances tumorigenic responses when enriched in the nucleus.Oncotarget · 2014Article
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7 authors at 3 institutions in 3 countries.
Funding
Abstract
Renal dysplasia, defined by defective ureteric branching morphogenesis and nephrogenesis, is the major cause of renal failure in infants and children. Here, we define a pathogenic role for a β-catenin-activated genetic pathway in murine renal dysplasia. Stabilization of β-catenin in the ureteric cell lineage before the onset of kidney development increased β-catenin levels and caused renal aplasia or severe hypodysplasia. Analysis of gene expression in the dysplastic tissue identified downregulation of genes required for ureteric branching and upregulation of Tgfβ2 and Dkk1. Treatment of wild-type kidney explants with TGFβ2 or DKK1 generated morphogenetic phenotypes strikingly similar to those observed in mutant kidney tissue. Stabilization of β-catenin after the onset of kidney development also caused dysplasia and upregulation of Tgfβ2 and Dkk1 in the epithelium. Together, these results demonstrate that elevation of β-catenin levels during kidney development causes dysplasia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.