ArticleProceedings of the National Academy of Sciences of the United States of America1990
Hypothesis: lipoprotein(a) is a surrogate for ascorbate.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 66 citations in OpenAlex.
- Lipoprotein(a) Lowering-From Lipoprotein Apheresis to Antisense Oligonucleotide Approach.Journal of clinical medicine · 2020Review
- Vitamin C inhibits the calcification process in human vascular smooth muscle cells.American journal of cardiovascular disease · 2020Article
- A Standard Lipid Panel Is Insufficient for the Care of a Patient on a High-Fat, Low-Carbohydrate Ketogenic Diet.Frontiers in medicine · 2020Article
- Lipoprotein (a): a promising prognostic biomarker in patients with hepatocellular carcinoma after curative resection.OncoTargets and therapy · 2018Article
- Lipoprotein(a) and vitamin C impair development of breast cancer tumors in Lp(a)+; Gulo-/- mice.International journal of oncology · 2016Article
- Inhibition of collagen synthesis by select calcium and sodium channel blockers can be mitigated by ascorbic acid and ascorbyl palmitate.American journal of cardiovascular disease · 2016Article
- Hypoascorbemia induces atherosclerosis and vascular deposition of lipoprotein(a) in transgenic mice.American journal of cardiovascular disease · 2015Article
- Mathematical modeling the neuroregulation of blood pressure using a cognitive top-down approach.North American journal of medical sciences · 2010Article
- Connective tissue: Vascular and hematological (blood) support.Journal of chiropractic medicine · 2003Article
- Abiotrophic gene action in Homo sapiens: potential mechanisms and significance for the pathobiology of aging.Genetica · 1993Review
- Immunological evidence for the accumulation of lipoprotein(a) in the atherosclerotic lesion of the hypoascorbemic guinea pig.Proceedings of the National Academy of Sciences of the United States of America · 1990Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The concept that lipoprotein(a) [Lp(a)] is a surrogate for ascorbate is suggested by the fact that this lipoprotein is found generally in the blood of primates and the guinea pig, which have lost the ability to synthesize ascorbate, but only rarely in the blood of other animals. Properties of Lp(a) that are shared with ascorbate, in accordance with this hypothesis, are the acceleration of wound healing and other cell-repair mechanisms, the strengthening of the extracellular matrix (e.g., in blood vessels), and the prevention of lipid peroxidation. High plasma Lp(a) is associated with coronary heart disease and other forms of atherosclerosis in humans, and the incidence of cardiovascular disease is decreased by elevated ascorbate. Similar observations have been made in cancer and diabetes. We have formulated the hypothesis that Lp(a) is a surrogate for ascorbate in humans and other species and have marshaled the evidence bearing on this hypothesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.