Evidence map›Paper›PMID 21435708›Full record

ReviewLancet (London, England)2011

Viral pneumonia.

Olli Ruuskanen, Elina Lahti, Lance C Jennings, David R Murdoch

5 registry-linked trialsOpen access · bronzeAbstract readReview
In one paragraph

Review in Lancet (London, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 599 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
599citing papers in PubMed, 2 pooled it
40.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04342637 completednot on this mapstarted 2020, after this paper: background citation

Gastrointestinal Endoscopy in the Era of COVID-19: a Multinational Survey

TypeobservationalSponsorAl-Azhar UniversityRan2020 to 2020Enrolled163ConditionsCOVID-19ArmsPractice details
NCT04359095 phase2 / phase3completednot on this mapstarted 2020, after this paper: background citation

Effectiveness and Safety of Medical Treatment for SARS-CoV-2 (COVID-19) in Colombia: A Pragmatic Randomized Controlled Trial

TypeinterventionalSponsorUniversidad Nacional de ColombiaRan2020 to 2021Enrolled650ConditionsCOVID-19ArmsEmtricitabine/tenofovir, Colchicine Pill, Rosuvastatin, Standard treatment
NCT04497311 unknown statusnot on this mapstarted 2020, after this paper: background citation

Pulmonary Tomographic Findings in COVID-19 and Influenza H1N1 Patients

TypeobservationalSponsorUniversidad de GuanajuatoRan2020 to 2022Enrolled100ConditionsSARS-CoV-2, Covid19, H1N1 Influenza, Computed TomographyArmsThoraxic computed tomography
NCT04499378 unknown statusnot on this mapstarted 2020, after this paper: background citation

Pulmonary Tomographic Findings in COVID-19 and Influenza H1N1 Patients at IMSS Guanajuato

TypeobservationalSponsorUniversidad de GuanajuatoRan2020 to 2022Enrolled200ConditionsCovid19, Influenza A H1N1, Intubation Complication, MoralityArmsLung CT
NCT06627166 terminatednot on this mapstarted 2022, after this paper: background citation

Clinical and Virological Characterization of Severe Acute Respiratory Infection Using PCR-Based Methods and Metagenomic Sequencing: a National Registry in Saudi Arabia

Typeobservational_patient_registrySponsorKing Abdullah International Medical Research CenterRan2022 to 2022Enrolled13ConditionsSevere Acute Respiratory Infection
3 · Its place in the literature

Who cites it

599 citing papers in PubMed, 2 syntheses or guidelines pooled it, 1,090 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
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  5. Trial
  6. Article
  7. Review
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  10. Anatomy-resolved digital twin framework for personalized light dosimetry in lung therapies.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Immune cell disorder in viral pneumonia.Journal of translational medicine · 2026
    Review
  18. Article
  19. Article
  20. Article

539 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Olli RuuskanenDepartment of Paediatrics, Turku University Hospitals, Turku, Finland. olli.ruuskanen@tyks.fi
Elina Lahti
Lance C Jennings
David R Murdoch
Canterbury Health Laboratories · NZTurku University Hospital · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

About 200 million cases of viral community-acquired pneumonia occur every year-100 million in children and 100 million in adults. Molecular diagnostic tests have greatly increased our understanding of the role of viruses in pneumonia, and findings indicate that the incidence of viral pneumonia has been underestimated. In children, respiratory syncytial virus, rhinovirus, human metapneumovirus, human bocavirus, and parainfluenza viruses are the agents identified most frequently in both developed and developing countries. Dual viral infections are common, and a third of children have evidence of viral-bacterial co-infection. In adults, viruses are the putative causative agents in a third of cases of community-acquired pneumonia, in particular influenza viruses, rhinoviruses, and coronaviruses. Bacteria continue to have a predominant role in adults with pneumonia. Presence of viral epidemics in the community, patient's age, speed of onset of illness, symptoms, biomarkers, radiographic changes, and response to treatment can help differentiate viral from bacterial pneumonia. However, no clinical algorithm exists that will distinguish clearly the cause of pneumonia. No clear consensus has been reached about whether patients with obvious viral community-acquired pneumonia need to be treated with antibiotics. Apart from neuraminidase inhibitors for pneumonia caused by influenza viruses, there is no clear role for use of specific antivirals to treat viral community-acquired pneumonia. Influenza vaccines are the only available specific preventive measures. Further studies are needed to better understand the cause and pathogenesis of community-acquired pneumonia. Furthermore, regional differences in cause of pneumonia should be investigated, in particular to obtain more data from developing countries.

Indexed as

Pneumonia, ViralAdultAge DistributionAge FactorsAntiviral AgentsBiomarkersChildCommunity-Acquired InfectionsComorbidityDeveloping CountriesDiagnosis, DifferentialGlobal HealthHumansImmunocompetenceLungPandemicsAntiviral AgentsBiomarkers

Identifiers

PMID21435708
PMCPMC7138033
OpenAlexW4205623122

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.