ArticleMolecular microbiology2011
Ancestral sporulation initiation.
Article in Molecular microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Sporulation modulates viscoelastic development through extracellular matrix restructuring inbioRxiv : the preprint server for biology · 2026Article
- Exploring the Influence of pH on the Dynamics of Acetone-Butanol-Ethanol Fermentation.Microorganisms · 2023Article
- Review
- Prediction of protein architectures involved in the signaling-pathway initiating sporulation in Firmicutes.BMC research notes · 2019Article
- Flexibility and constraint: Evolutionary remodeling of the sporulation initiation pathway in Firmicutes.PLoS genetics · 2018Article
- Immunoactive Clostridial Membrane Vesicle Production Is Regulated by a Sporulation Factor.Infection and immunity · 2017Article
- Article
- The genomic basis for the evolution of a novel form of cellular reproduction in the bacterium Epulopiscium.BMC genomics · 2012Article
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Members of the classes Bacilli and Clostridia are able to form endospores, with clostridia representing the ancestral phylogenetic line. In contrast to Bacillus subtilis, the process of sporulation initiation at the molecular level is less well understood in Clostridium acetobutylicum, the model organism of the clostridia. Especially the question of how the master regulator of sporulation, Spo0A, becomes phosphorylated, remained unsolved so far. Steiner et al. now provide compelling genetic and biochemical evidence for two different pathways of direct phosphorylation of Spo0A in C. acetobutylicum by three orphan sensor kinases. Cac0903 and Cac3319 act together, while the other pathway is only dependent on Cac0323. Abortion of sporulation initiation can be achieved by a kinase-like protein, Cac0437.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.