ArticleMolecular microbiology2011
MecA dampens transitions to spore, biofilm exopolysaccharide and competence expression by two different mechanisms.
Article in Molecular microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- ComK-induced cell death is reversed by upregulating the SigB or Spx pathway inMicrobiology spectrum · 2025Article
- MecA: A Multifunctional ClpP-Dependent and Independent Regulator in Gram-Positive Bacteria.Molecular microbiology · 2025Review
- Developmentally regulated proteolysis by MdfA and ClpCP mediates metabolic differentiation duringGenes & development · 2025Article
- Mass spectrometry and split luciferase complementation assays reveal the MecA protein interactome ofMicrobiology spectrum · 2024Article
- Impact of Protein Aggregates on Sporulation and Germination ofMicroorganisms · 2023Article
- Comparative Study ofFrontiers in cellular and infection microbiology · 2022Article
- ClpP participates in stress tolerance, biofilm formation, antimicrobial tolerance, and virulence of Enterococcus faecalis.BMC microbiology · 2020Article
- Genome analysis of a thermophilic exopolysaccharide-producing bacterium - Geobacillus sp. WSUCF1.Scientific reports · 2019Article
- ClpC and MecA, components of a proteolytic machine, prevent Spo0A-P-dependent transcription without degradation.Molecular microbiology · 2018Article
- Deficiency of MecA inFrontiers in microbiology · 2018Article
- Quality Control by Isoleucyl-tRNA Synthetase of Bacillus subtilis Is Required for Efficient Sporulation.Scientific reports · 2017Article
- Article
- Construction of a Super-Competent Bacillus subtilis 168 Using the P mtlA -comKS Inducible Cassette.Frontiers in microbiology · 2015Article
- Control of natural transformation in salivarius Streptococci through specific degradation of σX by the MecA-ClpCP protease complex.Journal of bacteriology · 2014Article
- Chance and Necessity in Bacillus subtilis Development.Microbiology spectrum · 2013Article
- The Staphylococcus aureus thiol/oxidative stress global regulator Spx controls trfA, a gene implicated in cell wall antibiotic resistance.Antimicrobial agents and chemotherapy · 2013Article
- Role of a GntR-family response regulator LbrA in Listeria monocytogenes biofilm formation.PloS one · 2013Article
- Spo0A~P imposes a temporal gate for the bimodal expression of competence in Bacillus subtilis.PLoS genetics · 2012Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The adapter protein MecA targets the transcription factor ComK for degradation by the ClpC/ClpP proteolytic complex, thereby negatively regulating competence in Bacillus subtilis. Here we show that MecA also decreases the frequency of transitions to the sporulation pathway as well as the expression of eps, which encodes synthesis of the biofilm matrix exopolysaccharide. We present genetic and biophysical evidence that MecA downregulates eps expression and spore formation by directly interacting with Spo0A. MecA does not target Spo0A for degradation, and apparently does not prevent the phosphorylation of Spo0A. We propose that it inhibits the transcriptional activity of Spo0A∼P by direct binding. Thus, in its interaction with Spo0A, MecA differs from its role in the regulation of competence where it targets ComK for degradation. MecA acts as a general buffering protein for development, acting by two distinct mechanisms to regulate inappropriate transitions to energy-intensive pathways.
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