ArticleCell and tissue research1990
Protein gene product 9.5-immunoreactive nerve fibres and cells in human skin.
Article in Cell and tissue research, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 244 citations in OpenAlex.
- Immunohistochemical localization of nerve fibers in the pseudocapsule of fibroids.European journal of histochemistry : EJH · 2014Trial
- Subtype- and Site-Specific Innervation of Melanocytic Nevi as Revealed by PGP 9.5 and CGRP Expression.Medicina (Kaunas, Lithuania) · 2025Article
- Intraepidermal Nerve Fiber Density as an Indicator of Neuropathy Predisposition: A Systematic Review with Meta-Analysis.Diagnostics (Basel, Switzerland) · 2025Review
- Small Fibre Pathology in Fibromyalgia: A review.Pain and therapy · 2025Review
- Skin Punch as a Potential Diagnostic Tool for Peripheral Neuropathies of Dogs: Set up of an Indirect Immunofluorescence Protocol on Formalin-Fixed Paraffin-Embedded (FFPE) Biopsy.Veterinary sciences · 2025Article
- Networks of Nerve Fibers, and Blood and Lymphatic Vessels in the Mouse Auricle: The Structural Basis of Ear Acupuncture.Medical acupuncture · 2024Article
- Discontinuity third harmonic generation microscopy for label-free imaging and quantification of intraepidermal nerve fibers.Cell reports methods · 2024Article
- Assessment of intraepidermal nerve fiber densities in 5 µm sections from arm and leg - a search for normative age-related values.Free neuropathology · 2024Article
- Quantifying innervation facilitated by deep learning in wound healing.Scientific reports · 2023Article
- Quantifying innervation facilitated by deep learning in wound healing.Research square · 2023Article
- Abnormal Intraepidermal Nerve Fiber Density in Disease: A Scoping Review.medRxiv : the preprint server for health sciences · 2023Article
- Abnormal intraepidermal nerve fiber density in disease: A scoping review.Frontiers in neurology · 2023Article
- Skin biopsy and small fibre neuropathies: facts and thoughts 30 years later.Journal of neurology, neurosurgery, and psychiatry · 2022Article
- Increased Epidermal Nerve Growth Factor without Small-Fiber Neuropathy in Dermatomyositis.International journal of molecular sciences · 2022Article
- Exosomes Derived From Umbilical Cord Mesenchymal Stem Cells Treat Cutaneous Nerve Damage and Promote Wound Healing.Frontiers in cellular neuroscience · 2022Article
- Investigation of nerve fibers in the skin by biopsy: technical aspects, indications, and contribution to diagnosis of small-fiber neuropathy.Einstein (Sao Paulo, Brazil) · 2022Article
- Contribution of Skin Biopsy in Peripheral Neuropathies.Brain sciences · 2020Review
- Lifting the veil on the keratinocyte contribution to cutaneous nociception.Protein & cell · 2020Review
- Small-fiber neuropathy definition, diagnosis, and treatment.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Review
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sections of human skin were processed according to the indirect immunofluorescence technique with a rabbit antiserum against human protein gene product 9.5 (PGP 9.5). Immunoreactivity was detected in intraepidermal and dermal nerve fibres and cells. The intraepidermal nerves were varicose or smooth with different diameters, running as single processes or branched, straight or bent, projecting in various directions and terminating in the stratum basale, spinosum or granulosum. The density of the intraepidermal nerves varied between the different skin areas investigated. PGP 9.5-containing axons of the lower dermis were found in large bundles. They separated into smaller axon bundles within the upper dermis, entering this portion of the skin perpendicular to the surface. Then they branched into fibres mainly arranged parallel to the epidermal-dermal junctional zone. However, the fibres en route to the epidermis traversed the upper dermis more or less perpendicularly. Furthermore, immunoreactive dermal nerve fibres were found in the Meissner corpuscles, the arrector pili muscles, hair follicles, around the eccrine and apocrine sweat glands and around certain blood vessels. Such fibres were also observed around most subcutaneous blood vessels, sometimes heavily innervating these structures. Numerous weakly-to-strongly PGP 9.5-immunoreactive cells were found both in the epidermis and in the dermis.
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