Evidence map›Paper›PMID 21433039›Full record

ArticleHepatology (Baltimore, Md.)2011

Silibinin mode of action against hepatitis C virus: a controversy yet to be resolved.

Harel Dahari, Jeremie Guedj, Alan S Perelson

Abstract readLetterComment
In one paragraph

Article in Hepatology (Baltimore, Md.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Sustained virological response with intravenous silibinin: individualized IFN-free therapy via real-time modelling of HCV kinetics.Liver international : official journal of the International Association for the Study of the Liver · 2015
    Article
  4. Article
  5. Article
  6. Silymarin for HCV infection.Antiviral therapy · 2013
    Review
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Harel Dahari
Jeremie Guedj
Alan S Perelson

Funding

Collaborative Integration of HCV Molecular Virology and Mathematical ModelingR01AI078881 · NIAID · UNIVERSITY OF ILLINOIS AT CHICAGO · PI PERELSON, ALAN S, UPRICHARD, SUSAN L. · 2011 to 2025
$7.5M
HIV Antiretroviral Therapy and Hepatic InjuryR01AI065256 · NIAID · UNIVERSITY OF CINCINNATI · PI SHERMAN, KENNETH E · 2006 to 2019
$5.5M
Modeling Viral and T Lymphocyte DynamicsR01OD011095 · OD · TRIAD NATIONAL SECURITY, LLC · PI PERELSON, ALAN S · 2012 to 2024
$5.0M
MODELING VIRAL AND T LYMPHOCYTE DYNAMICSR01RR006555 · NCRR · UNIVERSITY OF CALIF-LOS ALAMOS NAT LAB · PI PERELSON, ALAN S · 1991 to 2011
$3.9M
Immune System Modeling/HIVR01AI028433 · NIAID · UNIVERSITY OF CALIF-LOS ALAMOS NAT LAB · PI PERELSON, ALAN S · 1990 to 2021
$3.7M
Immune System Modeling/HIVR37AI028433 · NIAID · UNIVERSITY OF CALIF-LOS ALAMOS NAT LAB · PI PERELSON, ALAN S · 2002 to 2011
$2.4M
HIV Antiretroviral Therapy and Hepatic InjuryR56AI065256 · NIAID · UNIVERSITY OF CINCINNATI · PI SHERMAN, KENNETH E · 2014 to 2014
$535k
NCRR NIH HHS R01 RR006555NIAID NIH HHS R01 AI028433NIAID NIH HHS R01 AI065256NIAID NIH HHS R01 AI078881NIAID NIH HHS R37 AI028433NIAID NIH HHS R56 AI065256NIH HHS R01 OD011095
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

HepacivirusHumansSilybinSilymarinSilybinSilymarin

Identifiers

PMID21433039
PMCPMC3677944

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.