ArticleEnvironmental health and preventive medicine2010
Otitis, rhinitis, and atopy in relation to domestic endotoxin and β-glucan exposure among children in Singapore.
Article in Environmental health and preventive medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 3 citations in OpenAlex.
- Fungal exposure, atopy, and asthma exacerbations in Puerto Rican children.Annals of the American Thoracic Society · 2014Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExposure to microbial cell wall agents (MCWAs) has been related to the risk for atopy, otitis, and rhinitis.
objectivesTo relate domestic exposure to two important MCWAs-β-glucan and endotoxin-to the risk for otitis, rhinitis, atopy, and allergy in a sample of children from Singapore.
methodsSubjects (n = 98) were recruited from July 2006 to December 2008. Blood samples were taken to determine nonspecific IgE and skin prick tests were performed. Dust samples were collected from the bedrooms of the subjects and analyzed for the content of β-glucan and endotoxin, using the Limulus method.
resultsLevels of IgE were significantly higher among children with rhinitis, and these children also had a larger proportion of atopics. There were no differences in β-glucan values between children with otitis, children with rhinitis, and controls. Endotoxin levels were lower in the homes of children with otitis, with a tendency for the levels to be lower in those with rhinitis. Among children with a high level of β-glucan, there was a higher proportion of those with high IgE values and atopy.
conclusionsThe results suggest that a low level of endotoxin is a risk factor for otitis and that a high level of β-glucan is a risk factor for atopic sensitisation. Reactions to domestic indoor exposure are determined by several indoor agents and their relative exposure levels.
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Registered trials
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