ArticleThe journal of physiological sciences : JPS2011
Chemical structures of odorants that suppress ion channels in the olfactory receptor cell.
Article in The journal of physiological sciences : JPS, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 12 citations in OpenAlex.
- Suppression of olfactory signal transduction by insecticides.NPJ science of food · 2019Article
- 2,4,6-trichloroanisole is a potent suppressor of olfactory signal transduction.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been proposed that odorant suppression of the cyclic nucleotide-gated (CNG) channel is responsible for olfactory masking. In this study, the effect of odorant chain length and functional group on this suppression was investigated. Because similar suppression has been observed for voltage-gated channels also, we used voltage-gated Na channels in the olfactory receptor cell as a tool for substance screening. These features were then re-examined using CNG channels. Interestingly, both CNG and Na channels were suppressed in a similar manner-carboxylic acids had little effect and suppression became stronger when the chain length of the alcohol or ester was increased. Degree of suppression was correlated with the distribution coefficients (Log D), irrespective of the molecules used. Results obtained here may provide information for the development of novel masking agents based on molecular architecture.
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Registered trials
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