ArticleInternational journal of colorectal disease2011
Spatiotemporal expression of Wnt5a during the development of the hindgut and anorectum in human embryos.
Article in International journal of colorectal disease, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed, 15 citations in OpenAlex.
- Spatial transcriptomics reveals gene interactions and signaling pathway dynamics in rat embryos with anorectal malformation.Cell biology and toxicology · 2024Article
- Spatiotemporal Expression of Bcl-2/Bax and Neural Cell Apoptosis in the Developing Lumbosacral Spinal Cord of Rat Fetuses with Anorectal Malformations.Neurochemical research · 2017Article
- The great divide: septation and malformation of the cloaca, and its implications for surgeons.Pediatric surgery international · 2014Review
- Spatiotemporal expression of Wnt5a during the development of the striated muscle complex in rats with anorectal malformations.International journal of clinical and experimental pathology · 2014Article
- Wnt5a signaling promotes apical and basolateral polarization of single epithelial cells.Molecular biology of the cell · 2013Article
- Anorectal malformation associated with a mutation in the P63 gene in a family with split hand-foot malformation.International journal of colorectal disease · 2013Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of the study was to determine the spatiotemporal expression of Wnt5a during hindgut and anorectum development in human embryos and to explore the possible role of Wnt5a during the morphogenesis of the human hindgut and anorectum. MATERIALS AND
methodsThe embryos (n = 107) were sectioned serially and sagittally, using Wnt5a immunohistochemical staining on the caudal midline from the 4th-9th weeks of gestation.
resultsFrom the 4th-7th week of gestation, the Wnt5a-positive cells were mainly located on the epithelium of the apical urorectal septum, hindgut, and cloacal membrane. After the anorectum and the urogenital sinus (UGS) opened to the amniotic cavity during the 7th week, the Wnt5a-positive cells disappeared and remained negative up to the 9th week on the epithelium of the anal canal.
conclusionsThe expression of Wnt5a was constantly active during human hindgut and anorectum development and disappeared after the anus formed, suggesting that Wnt5a plays an important role in human hindgut and anorectal morphogenesis.
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